ArticleNeuroImage2022
Reproducibility of the Standard Model of diffusion in white matter on clinical MRI systems.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Early axonal degeneration linked to clinical decline in Alzheimer's disease progression revealed with diffusion MRI.The Journal of clinical investigation · 2026Trial
- Beyond Directions: Symmetry-Aware Rotation Sets for Triaxial Diffusion Encoding by Geometric Filter Optimization.Magnetic resonance in medicine · 2026Article
- Disentangling pontine fiber geometry and microstructure in ARSACS using advanced MRI.NeuroImage. Clinical · 2026Article
- Standard Model Imaging in the Brain and Spinal Cord of MS Patients: Initial Assessment and Comparison to Diffusion Tensor Imaging.NMR in biomedicine · 2026Article
- Axon Diameter Mapping From Myelin Water Diffusion MRI.IEEE transactions on medical imaging · 2026Article
- Multimodal Quantitative MRI of White and Gray Matter: Associations with Myelin-Related Metrics in the Healthy Adult Brain Using Synthetic MRI and IVIM-DWI.Journal of clinical medicine · 2026Article
- Biophysical Diffusion MRI Models Better Identify White Matter Tracts in Edema.Tomography (Ann Arbor, Mich.) · 2026Article
- The microstructure-weighted human connectome: network properties and structure-function correlations across spatial scales.bioRxiv : the preprint server for biology · 2026Article
- Diffusion MRI experimental design optimization for microstructure imaging.Communications biology · 2026Article
- Diagnosis of Multiple Sclerosis Using Multimodal Deep Learning Integrating Lesion and Normal-Appearing White Matter: A Retrospective Study with International Multicentre External Validation.medRxiv : the preprint server for health sciences · 2026Article
- Linking Symptom Phenotypes to Patterns of White Matter Injury in Mild Traumatic Brain Injury: A Latent Class Analysis.AJNR. American journal of neuroradiology · 2026Article
- Monte Carlo Assessment of Accuracy for Mean Kärger Model Water Exchange Rate Estimates From Diffusional Kurtosis Time Dependence.NMR in biomedicine · 2026Article
- What If Each Voxel Were Measured With a Different Diffusion Protocol?Magnetic resonance in medicine · 2026Article
- White matter microstructure differences in obstructive sleep apnea severity groups assessed by diffusion tensor metrics and biophysical modeling.Scientific reports · 2026Article
- DeepFixel: Crossing white matter fiber identification through spherical convolutional neural networks.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Thermal noise lowers the accuracy of rotationally invariant harmonics of diffusion MRI data and their robustness to experimental variations.Magnetic resonance in medicine · 2026Article
- Tensor-derived diffusion MRI metrics and NODDI in multiple sclerosis classification.NeuroImage. Clinical · 2026Article
- Reduced NEXI protocol for the quantification of human gray matter microstructure on the Connectome 2.0 scanner.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Advanced microstructure imaging at high b-values and high resolution combining ultra-high performance gradient diffusion imaging and model-based deep learning demonstrated using 3D multi-slab acquisition.Magnetic resonance in medicine · 2026Article
- Data-driven classification of tissue water populations by massively multidimensional diffusion-relaxation correlation MRI.Frontiers in neuroscience · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Estimating intra- and extra-axonal microstructure parameters, such as volume fractions and diffusivities, has been one of the major efforts in brain microstructure imaging with MRI. The Standard Model (SM) of diffusion in white matter has unified various modeling approaches based on impermeable narrow cylinders embedded in locally anisotropic extra-axonal space. However, estimating the SM parameters from a set of conventional diffusion MRI (dMRI) measurements is ill-conditioned. Multidimensional dMRI helps resolve the estimation degeneracies, but there remains a need for clinically feasible acquisitions that yield robust parameter maps. Here we find optimal multidimensional protocols by minimizing the mean-squared error of machine learning-based SM parameter estimates for two 3T scanners with corresponding gradient strengths of 40and80mT/m. We assess intra-scanner and inter-scanner repeatability for 15-minute optimal protocols by scanning 20 healthy volunteers twice on both scanners. The coefficients of variation all SM parameters except free water fraction are ≲10% voxelwise and 1-4% for their region-averaged values. As the achieved SM reproducibility outcomes are similar to those of conventional diffusion tensor imaging, our results enable robust in vivo mapping of white matter microstructure in neuroscience research and in the clinic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.