Evidence map›Paper›PMID 35545085›Full record

ArticleCurrent biology : CB2022

Local translation provides the asymmetric distribution of CaMKII required for associative memory formation.

Nannan Chen, Yunpeng Zhang, Mohamed Adel, Elena A Kuklin, Martha L Reed, Jacob D Mardovin, Baskar Bakthavachalu, K VijayRaghavan, Mani Ramaswami, Leslie C Griffith

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Degradation of CaMKII is stimulated by its active conformation.The Journal of biological chemistry · 2025
    Article
  5. Review
  6. Future avenues inLearning & memory (Cold Spring Harbor, N.Y.) · 2024
    Review
  7. Review
  8. Review
  9. Pairing-Dependent Plasticity in a Dissected Fly Brain Is Input-Specific and Requires Synaptic CaMKII Enrichment and Nighttime Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Nannan ChenDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA.
Yunpeng ZhangDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA.
Mohamed AdelDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA.
Elena A KuklinDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA.
Martha L ReedDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA.
Jacob D MardovinDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA.
Baskar BakthavachaluNational Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560065, India; School of Basic Science, Indian Institute of Technology Mandi, Mandi, India.
K VijayRaghavanNational Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560065, India; School of Basic Science, Indian Institute of Technology Mandi, Mandi, India.
Mani RamaswamiTrinity College Institute of Neuroscience, School of Genetics and Microbiology and School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560065, India; School of Basic Science, Indian Institute of Technology Mandi, Mandi, India.
Leslie C GriffithDepartment of Biology, Volen National Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA. Electronic address: griffith@brandeis.edu.
Brandeis University · USTata Institute of Fundamental Research · IN

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Regulation of Intrinsic Plasticity in Neural CircuitsR01MH067284 · NIMH · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 2003 to 2025
$8.8M
Activity-Dependent Regulation of CaMKII and Synaptic PlasticityR37NS112810 · NINDS · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 2019 to 2025
$2.9M
Undergraduate and Graduate Training in Computational Neuroscience R90DA033463 · NIDA · BRANDEIS UNIVERSITY · PI MILLER, PAUL · 2011 to 2020
$2.0M
Role of CaMKII in memory storageR01NS103168 · NINDS · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 2017 to 2021
$1.8M
CRCNS: Neural signals that maintain/refresh LTP and memoryR01DA043195 · NIDA · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 2017 to 2019
$1.1M
NIDA NIH HHS R01 DA043195NIDA NIH HHS R90 DA033463NIH HHS P40 OD018537NIMH NIH HHS R01 MH067284NINDS NIH HHS R01 NS103168NINDS NIH HHS R37 NS112810Wellcome Trust
6 · The paper itself

Abstract

How compartment-specific local proteomes are generated and maintained is inadequately understood, particularly in neurons, which display extreme asymmetries. Here we show that local enrichment of Ca

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase Type 2NeuronsAnimalsDrosophilaMushroom BodiesRNA, MessengerCalcium-Calmodulin-Dependent Protein Kinase Type 2RNA, Messengeraxonal translationcalcium/calmodulin-dependent protein kinase IIDrosophilamushroom bodyRNA-binding proteinsynaptic plasticity

Identifiers

PMID35545085
PMCPMC9233017
OpenAlexW4280543184

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.