Evidence map›Paper›PMID 35545045›Full record

ArticleCell reports2022

Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations.

Abigail P Leinroth, Anthony J Mirando, Douglas Rouse, Yoshihiko Kobayahsi, Purushothama Rao Tata, Helen E Rueckert, Yihan Liao, Jason T Long, Joe V Chakkalakal, Matthew J Hilton

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
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  5. Review
  6. Review
  7. Article
  8. Mapping the Tissue-of-Origins of Mesenchymal Stromal Cells in Injury Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Article
  10. Article
  11. Intramuscular adipose tissue: from progenitor to pathology.American journal of physiology. Cell physiology · 2025
    Review
  12. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. PdgfrαGenes & diseases · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Abigail P LeinrothDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27708, USA.
Anthony J MirandoDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27708, USA.
Douglas RouseDivision of Laboratory Animal Resources, Duke University School of Medicine, Durham, NC 27708, USA.
Yoshihiko KobayahsiDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27708, USA.
Purushothama Rao TataDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27708, USA.
Helen E RueckertDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27708, USA.
Yihan LiaoDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27708, USA.
Jason T LongDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27708, USA.
Joe V ChakkalakalDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27708, USA.
Matthew J HiltonDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27708, USA; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27708, USA. Electronic address: matthew.hilton@duke.edu.
Duke University · US

Funding

Training Program in Developmental & Stem Cell BiologyT32HD040372 · NICHD · DUKE UNIVERSITY · PI Terry H Lechler · 2001 to 2026
$8.9M
Notch Signaling in Joint Cartilage Maintenance and ArthritisR01AR063071 · NIAMS · UNIVERSITY OF ROCHESTER · PI HILTON, MATTHEW J. · 2012 to 2021
$3.9M
Notch Signaling in Endochondral Bone DevelopmentR01AR071722 · NIAMS · DUKE UNIVERSITY · PI HILTON, MATTHEW J. · 2018 to 2022
$1.8M
Notch Signaling in non-myogenic mesenchymal cells regulates muscle developmentF31AR076180 · NIAMS · DUKE UNIVERSITY · PI LEINROTH, ABIGAIL · 2020 to 2022
$106k
NIAMS NIH HHS F31 AR076180NIAMS NIH HHS R01 AR063071NIAMS NIH HHS R01 AR071722NICHD NIH HHS T32 HD040372
6 · The paper itself

Abstract

Mesenchymal progenitors of the lateral plate mesoderm give rise to various cell fates within limbs, including a heterogeneous group of muscle-resident mesenchymal cells. Often described as fibro-adipogenic progenitors, these cells are key players in muscle development, disease, and regeneration. To further define this cell population(s), we perform lineage/reporter analysis, flow cytometry, single-cell RNA sequencing, immunofluorescent staining, and differentiation assays on normal and injured murine muscles. Here we identify six distinct Pdgfra

Indexed as

Muscle DevelopmentMuscle, SkeletalAdipogenesisAnimalsCell DifferentiationMiceMuscle Fibers, SkeletalCP: Developmental biologyFAPsfibro-adipogenic progenitorsnon-myogenic mesenchymal cellsskeletal muscle

Identifiers

PMID35545045
PMCPMC9535675
OpenAlexW4280505523

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.