ArticleCell reports2022
Movement-specific signaling is differentially distributed across motor cortex layer 5 projection neuron classes.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Cognitive-Motor Duality in Human M1 and Cerebellum.Research square · 2026Article
- A cortical output channel for perceptual categorization.Science advances · 2026Article
- Article
- A transparent wheel-based platform for locomotion-on-demand and multi-view body and facial kinematics in head-fixed mice.Scientific reports · 2026Article
- Diversity in Whisking-Related Dynamics of Layer 5 Neurons in the Motor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Site-specific noninvasive delivery of retrograde viral vectors to the brain.Bioengineering & translational medicine · 2026Article
- Decoupling of motor cortex to movement in Parkinson's dyskinesia rescued by sub-anaesthetic ketamine.Brain : a journal of neurology · 2025Article
- Learning and Control in Motor Cortex across Cell Types and Scales.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Cortico-basal ganglia plasticity in motor learning.Neuron · 2024Review
- Dopamine-mediated plasticity preserves excitatory connections to direct pathway striatal projection neurons and motor function in a mouse model of Parkinson's disease.bioRxiv : the preprint server for biology · 2024Article
- Topographical and cell type-specific connectivity of rostral and caudal forelimb corticospinal neuron populations.Cell reports · 2024Article
- Article
- Corticospinal Modulation of Precision Movements.Neuroscience insights · 2024Article
- Layer 5 Intratelencephalic Neurons in the Motor Cortex Stably Encode Skilled Movement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Motor cortex generates descending output necessary for executing a wide range of limb movements. Although movement-related activity has been described throughout motor cortex, the spatiotemporal organization of movement-specific signaling in deep layers remains largely unknown. Here we record layer 5B population dynamics in the caudal forelimb area of motor cortex while mice perform a forelimb push/pull task and find that most neurons show movement-invariant responses, with a minority displaying movement specificity. Using cell-type-specific imaging, we identify that invariant responses dominate pyramidal tract (PT) neuron activity, with a small subpopulation representing movement type, whereas a larger proportion of intratelencephalic (IT) neurons display movement-type-specific signaling. The proportion of IT neurons decoding movement-type peaks prior to movement initiation, whereas for PT neurons, this occurs during movement execution. Our data suggest that layer 5B population dynamics largely reflect movement-invariant signaling, with information related to movement-type being routed through relatively small, distributed subpopulations of projection neurons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.