Evidence map›Paper›PMID 35544705›Full record

ArticleACS applied bio materials2022

Mass Spectrometry, Structural Analysis, and Anti-Inflammatory Properties of Photo-Cross-Linked Human Albumin Hydrogels.

Shahriar Sharifi, Amir Ata Saei, Hassan Gharibi, Nouf N Mahmoud, Shannon Harkins, Naruphorn Dararatana, Erika M Lisabeth, Vahid Serpooshan, Ákos Végvári, Anna Moore and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS applied bio materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Amyloid-Based Albumin Hydrogels.Advanced healthcare materials · 2023
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Shahriar SharifiDepartment of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0002-3853-5428
Amir Ata SaeiDivision of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17 177 Stockholm, Sweden.ORCID 0000-0002-2639-6328
Hassan GharibiDivision of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17 177 Stockholm, Sweden.ORCID 0000-0002-3072-4929
Nouf N MahmoudDepartment of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0002-3870-7568
Shannon HarkinsDepartment of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0002-7272-9197
Naruphorn DararatanaDepartment of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States.
Erika M LisabethDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, United States.
Vahid SerpooshanDepartment of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, Georgia 30322, United States.ORCID 0000-0002-5304-095X
Ákos VégváriDivision of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17 177 Stockholm, Sweden.ORCID 0000-0002-1287-0906
Anna MooreDepartment of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States.
Morteza MahmoudiDepartment of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0002-2575-9684
Michigan State University · USKarolinska Institutet · SEAl-Zaytoonah University of Jordan · JOGeorgia Institute of Technology · USHarvard University · US

Funding

A Nanostructured Skin Patch to Heal Chronic WoundsR01DK131417 · NIDDK · MICHIGAN STATE UNIVERSITY · PI Morteza Mahmoudi · 2022 to 2026
$2.0M
NIDDK NIH HHS R01 DK131417
6 · The paper itself

Abstract

Albumin-based hydrogels offer unique benefits such as biodegradability and high binding affinity to various biomolecules, which make them suitable candidates for biomedical applications. Here, we report a non-immunogenic photocurable human serum-based (HSA) hydrogel synthesized by methacryloylation of human serum albumin by methacrylic anhydride (MAA). We used matrix-assisted laser desorption ionization-time-of-flight mass spectrometry, liquid chromatography-tandem mass spectrometry, as well as size exclusion chromatography to evaluate the extent of modification, hydrolytic and enzymatic degradation of methacrylated albumin macromer and its cross-linked hydrogels. The impacts of methacryloylation and cross-linking on alteration of inflammatory response and toxicity were evaluated

Indexed as

HydrogelsSerum Albumin, HumanAnti-Inflammatory AgentsBiocompatible MaterialsHumansMass SpectrometryAnti-Inflammatory AgentsBiocompatible MaterialsHydrogelsSerum Albumin, Humanalbuminhydrogelsinflammatory pathwaysmass spectrometrynon-immunogenicphotocurable gelsstructural analysis

Identifiers

PMID35544705
PMCPMC9668369
OpenAlexW4280536419

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.