ArticleScience translational medicine2022
Acute inflammatory response via neutrophil activation protects against the development of chronic pain.
Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 177 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Frontostriatal Connectivity and Gene Expression in Exercise-induced Relief of Back Pain
Neuroimmune Responses to Physical Exercise Training in Chronic Primary Low Back Pain
Who cites it
177 citing papers in PubMed, 9 syntheses or guidelines pooled it, 309 citations in OpenAlex.
- Altered blood-based biomarkers in carpal tunnel syndrome. A systematic review and meta-analysis.Musculoskeletal science & practice · 2026Pooled it
- Shedding light on pain management: a translational systematic review of light therapy for the treatment of chronic pain.EBioMedicine · 2026Pooled it
- Tr14 gel compared to diclofenac gel after acute unilateral ankle sprain: an Individual Patient Data (IPD) meta-analysis of two multi-center trials.BMC musculoskeletal disorders · 2026Pooled it
- Comparative transcriptomic meta-analysis reveals elevated TCL1A expression in human circulating immune cells across chronic pain conditions.British journal of anaesthesia · 2026Pooled it
- Pooled it
- Genome-wide association studies with experimental validation identify a protective role for B lymphocytes against chronic post-surgical pain.British journal of anaesthesia · 2024Pooled it
- Fucoidan as a Promising Drug for Pain Treatment: Systematic Review and Meta-Analysis.Marine drugs · 2024Pooled it
- Effect of use of NSAIDs or steroids during the acute phase of pain on the incidence of chronic pain: a systematic review and meta-analysis of randomised trials.Inflammopharmacology · 2024Pooled it
- The potential protective effects of pre-injury exercise on neuroimmune responses following experimentally-induced traumatic neuropathy: a systematic review with meta-analysis.Frontiers in immunology · 2023Pooled it
- Baseline characteristics of participants in the Biomarkers for Evaluating Spine Treatments clinical trial: a sequential multiple assignment randomized trial for chronic low back pain†.Pain medicine (Malden, Mass.) · 2025Trial
- Circadian rhythmicity and biopsychosocial characteristics influence opioid use in chronic low back pain.The Journal of clinical investigation · 2025Trial
- Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot study.Osteoarthritis and cartilage open · 2024Trial
- Randomized, double-blind, placebo-controlled study to evaluate the effect of treatment with an SPMs-enriched oil on chronic pain and inflammation, functionality, and quality of life in patients with symptomatic knee osteoarthritis: GAUDI study.Journal of translational medicine · 2023Trial
- TLR2 inhibition attenuates NET-driven inflammation and restenosis during poly-lactic acid bioresorbable scaffold degradation.Bioactive materials · 2026Article
- Elucidation of key lactylation- and palmitoylation-related genes and their related mechanisms in the development of neuropathic pain.Medicine · 2026Article
- β-Catenin-Deficient Intervertebral Disc Cells Reduce Chemotactic Transcription and Myeloid Cell Recruitment to Injured Discs of Mice.Aging cell · 2026Article
- Glial cells in neuropathic pain.Physiological reviews · 2026Review
- Chronic postsurgical pain in children: Current evidence and clinical perspectives.World journal of clinical pediatrics · 2026Review
- Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner.The journal of pain · 2026Article
- Use of Intravenous Lidocaine, Ketamine, and Magnesium for Acute Pain Control After Lung Resection Surgery: A Prospective Cohort Study.Journal of clinical medicine · 2026Article
117 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 9 institutions in 5 countries.
Funding
Abstract
The transition from acute to chronic pain is critically important but not well understood. Here, we investigated the pathophysiological mechanisms underlying the transition from acute to chronic low back pain (LBP) and performed transcriptome-wide analysis in peripheral immune cells of 98 participants with acute LBP, followed for 3 months. Transcriptomic changes were compared between patients whose LBP was resolved at 3 months with those whose LBP persisted. We found thousands of dynamic transcriptional changes over 3 months in LBP participants with resolved pain but none in those with persistent pain. Transient neutrophil-driven up-regulation of inflammatory responses was protective against the transition to chronic pain. In mouse pain assays, early treatment with a steroid or nonsteroidal anti-inflammatory drug (NSAID) also led to prolonged pain despite being analgesic in the short term; such a prolongation was not observed with other analgesics. Depletion of neutrophils delayed resolution of pain in mice, whereas peripheral injection of neutrophils themselves, or S100A8/A9 proteins normally released by neutrophils, prevented the development of long-lasting pain induced by an anti-inflammatory drug. Analysis of pain trajectories of human subjects reporting acute back pain in the UK Biobank identified elevated risk of pain persistence for subjects taking NSAIDs. Thus, despite analgesic efficacy at early time points, the management of acute inflammation may be counterproductive for long-term outcomes of LBP sufferers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.