Evidence map›Paper›PMID 35544004›Full record

ArticleExperientia supplementum (2012)2022

The Function and Structure of the Microsporidia Polar Tube.

Bing Han, Peter M Takvorian, Louis M Weiss

Open access · greenAbstract read
In one paragraph

Article in Experientia supplementum (2012), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Cryo-ET reveals the in situ architecture of the polar tube invasion apparatus from microsporidian parasites.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Germination of Microsporidian Spores: The Known and Unknown.Journal of fungi (Basel, Switzerland) · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Bing HanDepartment of Pathogenic Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.ORCID https://orcid.org/0000-0002-7299-2753
Peter M TakvorianDepartment of Pathology, Albert Einstein College of Medicine, New York, USA.ORCID https://orcid.org/0000-0001-5069-4352
Louis M WeissDepartment of Pathology, Albert Einstein College of Medicine, New York, USA. louis.weiss@einsteinmed.edu.ORCID https://orcid.org/0000-0002-0357-7396
Albert Einstein College of Medicine · USRutgers, The State University of New Jersey · US

Funding

TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
Microsporidia: invasion apparatusR01AI124753 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2016 to 2025
$4.2M
Development of Novel MetAP2 inhibitors as potential therapeutics for MicrosporidiosisR01AI132614 · NIAID · LONG ISLAND UNIVERSITY BROOKLYN CAMPUS · PI DAS, BHASKAR CHANDRA, WEISS, LOUIS M. · 2018 to 2022
$2.5M
Assembly dynamics and role of PI4P enriched replication organelles for enteroviraR01AI091985 · NIAID · RUTGERS THE STATE UNIV OF NJ NEWARK · PI CALI, ANN · 2011 to 2015
$2.0M
120kV Transmission Electron Microscope for a Multi-user Microscopy FacilityS10OD016214 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CONDEELIS, JOHN S · 2014 to 2014
$459k
NIAID NIH HHS R01 AI091985NIAID NIH HHS R01 AI124753NIAID NIH HHS R01 AI132614NIGMS NIH HHS P41 GM103310NIH HHS S10 OD016214
6 · The paper itself

Abstract

Microsporidia are obligate intracellular pathogens that were initially identified about 160 years ago. Current phylogenetic analysis suggests that they are grouped with Cryptomycota as a basal branch or sister group to the fungi. Microsporidia are found worldwide and can infect a wide range of animals from invertebrates to vertebrates, including humans. They are responsible for a variety of diseases once thought to be restricted to immunocompromised patients but also occur in immunocompetent individuals. The small oval spore containing a coiled polar filament, which is part of the extrusion and invasion apparatus that transfers the infective sporoplasm to a new host, is a defining characteristic of all microsporidia. When the spore becomes activated, the polar filament uncoils and undergoes a rapid transition into a hollow tube that will transport the sporoplasm into a new cell. The polar tube has the ability to increase its diameter from approximately 100 nm to over 600 nm to accommodate the passage of an intact sporoplasm and penetrate the plasmalemma of the new host cell. During this process, various polar tube proteins appear to be involved in polar tube attachment to host cell and can interact with host proteins. These various interactions act to promote host cell infection.

Indexed as

MicrosporidiaAnimalsCytoplasmHumansPhylogenySpores, FungalCell-host interactionDiagnosisMicrosporidiaMicrosporidiosisPolar filamentPolar tube proteinsSporeSpore wall proteins

Identifiers

PMID35544004
PMCPMC10037675
OpenAlexW4285158906

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.