ArticleExperientia supplementum (2012)2022
Impact of Genome Reduction in Microsporidia.
Article in Experientia supplementum (2012), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Worms About Town: a citizen science project discovers microsporidian parasites of nematodes through environmental sampling.Biology open · 2026Article
- Variation in Genome Architecture and Epigenetic Modification Across the Microsporidia Phylogeny.Genome biology and evolution · 2025Article
- Clade-wide fungal proteome analysis reveals structure-function conservation in divergent Dicer proteins.Computational and structural biotechnology journal · 2025Article
- Genome Structure, Evolution, and Host Shift ofBiology · 2024Article
- Revealing the genome of the microsporidian Vairimorpha bombi, a potential driver of bumble bee declines in North America.G3 (Bethesda, Md.) · 2024Article
- Polyploidy is widespread in Microsporidia.Microbiology spectrum · 2024Article
- Ultrastructural insights into the microsporidian infection apparatus reveal the kinetics and morphological transitions of polar tube and cargo during host cell invasion.PLoS biology · 2024Article
- PoMeLo: a systematic computational approach to predicting metabolic loss in pathogen genomes.BMC bioinformatics · 2024Article
- Treatment of MicrosporidiumMicroorganisms · 2024Article
- MicroAnnot: A Dedicated Workflow for Accurate Microsporidian Genome Annotation.International journal of molecular sciences · 2024Article
- Functional annotation of a divergent genome using sequence and structure-based similarity.BMC genomics · 2024Article
- Nematocida displodere mechanosensitive ion channel of small conductance 2 assembles into a unique 6-channel super-structure in vitro.PloS one · 2024Article
- Near chromosome-level genome assembly of the microsporidium Hamiltosporidium tvaerminnensis.G3 (Bethesda, Md.) · 2023Article
- A Putative TRAPα Protein of MicrosporidiaJournal of fungi (Basel, Switzerland) · 2023Article
- The dark side of the ribosome life cycle.RNA biology · 2022Article
- Minimization and complete loss of general transcription factor proteins in the intracellular parasiteTranscriptionArticle
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Microsporidia represent an evolutionary outlier in the tree of life and occupy the extreme edge of the eukaryotic domain with some of their biological features. Many of these unicellular fungi-like organisms have reduced their genomic content to potentially the lowest limit. With some of the most compacted eukaryotic genomes, microsporidia are excellent model organisms to study reductive evolution and its functional consequences. While the growing number of sequenced microsporidian genomes have elucidated genome composition and organization, a recent increase in complementary post-genomic studies has started to shed light on the impacts of genome reduction in these unique pathogens. This chapter will discuss the biological framework enabling genome minimization and will use one of the most ancient and essential macromolecular complexes, the ribosome, to illustrate the effects of extreme genome reduction on a structural, molecular, and cellular level. We outline how reductive evolution in microsporidia has shaped DNA organization, the composition and function of the ribosome, and the complexity of the ribosome biogenesis process. Studying compacted mechanisms, processes, or macromolecular machines in microsporidia illuminates their unique lifestyle and provides valuable insights for comparative eukaryotic structural biology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.