Evidence map›Paper›PMID 35543887›Full record

ArticleInternational journal of clinical oncology2022

Spread of lymph node metastasis and adjuvant therapy for distal cholangiocarcinoma.

Hiroshi Kurahara, Yuko Mataki, Tetsuya Idichi, Yota Kawasaki, Shinichiro Mori, Ken Sasaki, Takaaki Arigami, Akihiro Nakajo, Yoshihiko Fukukura, Michiyo Higashi and 1 more

Abstract read
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In one paragraph

Article in International journal of clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Role of Adjuvant Chemotherapy in Distal Cholangiocarcinoma.Journal of hepato-biliary-pancreatic sciences · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Hiroshi KuraharaDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan. h-krhr@m3.kufm.kagoshima-u.ac.jp.ORCID http://orcid.org/0000-0002-7735-9607
Yuko MatakiDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Tetsuya IdichiDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Yota KawasakiDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Shinichiro MoriDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Ken SasakiDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Takaaki ArigamiDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Akihiro NakajoDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Yoshihiko FukukuraDepartment of Radiology, Kagoshima University, Kagoshima, Japan.
Michiyo HigashiDepartment of Pathology, Kagoshima University, Kagoshima, Japan.
Takao OhtsukaDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Kagoshima University · JP

Funding

Ministry of Health, Labour and Welfare 20K21633
6 · The paper itself

Abstract

backgroundLymphatic metastasis is a major route of metastasis in distal cholangiocarcinoma (DCC). The present study aimed to elucidate the pattern of lymph node (LN) metastasis and the effectiveness of LN dissection and postoperative adjuvant chemotherapy in patients with DCC.

methodsPatients who underwent surgical resection with curative intent for DCC were enrolled. The nomenclature of the LN stations was defined according to the Japanese Society of Hepato-Biliary-Pancreatic Surgery guidelines. Effectiveness of LN dissection of each station was calculated using frequency of LN metastasis to the station and 5-year survival rate of patients with LN metastasis to that station.

resultsOf the 105 patients included in the study, 46 (43.8%) had LN metastasis, and 43 (41.0%) underwent postoperative adjuvant therapy. LN metastasis, serum carbohydrate antigen (CA) 19-9 level > 37 U/mL, and positive bile duct margin were independent risk factors for shorter overall survival (OS). The most common metastatic LN station at surgery was No. 13 (32.7%), followed by No. 12 (19.2%), No. 17 (9.6%), and No. 8 (6.6%). There was no effectiveness of LN dissection of the station No. 8, 14, and 16. Adjuvant chemotherapy was significantly associated with longer OS in patients with LN metastasis but not in those with positive ductal margins or serum CA 19-9 level > 37 U/mL.

conclusionsPostoperative adjuvant chemotherapy was associated with a better prognosis in patients with DCC and LN metastasis. However, a more effective therapeutic strategy is required to improve the prognosis of patients with other negative prognostic factors.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaBile Ducts, IntrahepaticCA-19-9 AntigenHumansLymphatic MetastasisLymph Node ExcisionMargins of ExcisionCA-19-9 AntigenBile duct cancerEffectiveness of lymph node dissectionEfficacy indexStation of lymph node

Identifiers

PMID35543887
OpenAlexW4280499181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.