Evidence map›Paper›PMID 35543796›Full record

ReviewJournal of thrombosis and thrombolysis2022

Acute coronary syndrome in patients with hemophilia: a delicate balancing act.

Jacob J Mayfield, Andrew D Leavitt, Talha Tanriverdi, Krishan Soni, Thomas A Ports, M Roselle Abraham

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of thrombosis and thrombolysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jacob J MayfieldDivision of Cardiology, Department of Medicine, University of Washington, 1959 NE Pacific St, Box 356422, Seattle, WA, 98195, USA. Jake.Mayfield@me.com.ORCID http://orcid.org/0000-0003-3780-6502
Andrew D LeavittDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Talha TanriverdiDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Krishan SoniDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Thomas A PortsDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
M Roselle AbrahamDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic advances have resulted in increased life expectancy in patients with hemophilia. Consequently, the prevalence of coronary artery disease in this population is increasing. Little is known about the optimal management of acute coronary syndrome in these patients. Current guidelines for the management of this condition are based mainly on expert opinion and generally recommend administration of the clotting factor prior to the anticoagulant, antiplatelet, and interventional therapies. We report a case that illustrates the potential harm that may come from this approach: evolution of non-ST-segment elevation acute coronary syndrome into ST-elevation acute coronary syndrome during the administration of recombinant clotting factor. We review available literature and describe the refined informatics-based guidelines for managing acute coronary syndrome in patients with hemophilia we developed in response to the presented clinical case. We propose adopting this novel informatics-based approach, which aids in the identification and early treatment of these patients, operationalizes timely involvement of hematology experts, and gathers data for further study.

Indexed as

Acute Coronary SyndromeCoronary Artery DiseaseHemophilia AAnticoagulantsHumansAnticoagulantsAcute coronary syndromeCoronary artery diseaseHemophiliaHemophilia AHemophilia B

Identifiers

PMID35543796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.