Evidence map›Paper›PMID 35543716›Full record

ArticleACS synthetic biology2022

Design, Analysis, and Implementation of a Novel Biochemical Pathway for Ethylene Glycol Production in

Barbara Bourgade, Christopher M Humphreys, James Millard, Nigel P Minton, M Ahsanul Islam

Open access · hybridAbstract read
In one paragraph

Article in ACS synthetic biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. The Chemistry of COChemical reviews · 2026
    Review
  2. Article
  3. Review
  4. Novel aspects of ethylene glycol catabolism.Applied microbiology and biotechnology · 2024
    Review
  5. Recent progress in engineeringSynthetic and systems biotechnology · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Barbara BourgadeDepartment of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, U.K.
Christopher M HumphreysBBSRC/EPSRC Synthetic Biology Research Centre, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, U.K.
James MillardBBSRC/EPSRC Synthetic Biology Research Centre, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, U.K.ORCID 0000-0001-9026-4453
Nigel P MintonBBSRC/EPSRC Synthetic Biology Research Centre, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, U.K.ORCID 0000-0002-9277-1261
M Ahsanul IslamDepartment of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, U.K.ORCID 0000-0001-9585-6263
University of Nottingham · GBLoughborough University · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L013940/1Biotechnology and Biological Sciences Research Council BB/R021503/1Biotechnology and Biological Sciences Research Council BB/T010630/1
6 · The paper itself

Abstract

The platform chemical ethylene glycol (EG) is used to manufacture various commodity chemicals of industrial importance, but largely remains synthesized from fossil fuels. Although several novel metabolic pathways have been reported for its bioproduction in model organisms, none has been reported for gas-fermenting, non-model acetogenic chassis organisms. Here, we describe a novel, synthetic biochemical pathway to convert acetate into EG in the industrially important gas-fermenting acetogen,

Indexed as

ClostridiumEthylene GlycolMetabolic EngineeringMetabolic Networks and PathwaysPlasmidsEthylene GlycolClostridium autoethanogenumethylene glycolmetabolic engineeringsynthetic biologysynthetic pathway

Identifiers

PMID35543716
PMCPMC9127970
OpenAlexW4280504698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.