Evidence map›Paper›PMID 35543507›Full record

ReviewPhysiological genomics2022

mRatBN7.2: familiar and unfamiliar features of a new rat genome reference assembly.

Tristan V de Jong, Hao Chen, Wesley A Brashear, Kelli J Kochan, Andrew E Hillhouse, Yaming Zhu, Isha S Dhande, Elizabeth A Hudson, Mary H Sumlut, Melissa L Smith and 2 more

Abstract readReview
In one paragraph

Review in Physiological genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tristan V de JongDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, Tennessee.
Hao ChenDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, Tennessee.
Wesley A BrashearTexas A&M Institute for Genome Sciences and Society, Texas A&M University, College Station, Texas.
Kelli J KochanTexas A&M Institute for Genome Sciences and Society, Texas A&M University, College Station, Texas.
Andrew E HillhouseTexas A&M Institute for Genome Sciences and Society, Texas A&M University, College Station, Texas.
Yaming ZhuCenter for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas McGovern School of Medicine, Houston, Texas.
Isha S DhandeCenter for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas McGovern School of Medicine, Houston, Texas.
Elizabeth A HudsonDepartment of Biochemistry and Molecular Genetics, University of Louisville, Louisville, Kentucky.
Mary H SumlutDepartment of Biochemistry and Molecular Genetics, University of Louisville, Louisville, Kentucky.ORCID 0000-0002-4621-7016
Melissa L SmithDepartment of Biochemistry and Molecular Genetics, University of Louisville, Louisville, Kentucky.
Theodore S KalbfleischDepartment of Veterinary Science, College of Agriculture, Food, and Environment, University of Kentucky, Lexington, Kentucky.
Peter A DorisCenter for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas McGovern School of Medicine, Houston, Texas.ORCID 0000-0002-0565-7939

Funding

System genetics of menthol and nicotine addictionU01DA047638 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CHEN, HAO, WILLIAMS, ROBERT W. · 2019 to 2023
$3.1M
Hypertensive Renal InjuryR01DK081866 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DORIS, PETER A · 2009 to 2017
$2.9M
Long-read assembly and annotation of rat genomes that are important models of complex genetic diseaseR01HG011252 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DORIS, PETER A, KALBFLEISCH, THEODORE · 2021 to 2025
$2.0M
NHGRI NIH HHS R01 HG011252NIDA NIH HHS U01 DA047638NIDDK NIH HHS R01 DK081866
6 · The paper itself

Abstract

Rat genomic tools have been slower to emerge than for those of humans and mice and have remained less thorough and comprehensive. The arrival of a new and improved rat reference genome, mRatBN7.2, in late 2020 is a welcome event. This assembly, like predecessor rat reference assemblies, is derived from an inbred Brown Norway rat. In this "user" survey we hope to provide other users of this assembly some insight into its characteristics and some assessment of its improvements as well as a few caveats that arise from the unique aspects of this assembly. mRatBN7.2 was generated by the Wellcome Sanger Institute as part of the large Vertebrate Genomes Project. This rat assembly has now joined human, mouse, chicken, and zebrafish in the National Center for Biotechnology Information (NCBI)'s Genome Reference Consortium, which provides ongoing curation of the assembly. Here we examine the technical procedures by which the assembly was created and assess how this assembly constitutes an improvement over its predecessor. We also indicate the technical limitations affecting the assembly, providing illustrations of how these limitations arise and the impact that results for this reference assembly.

Indexed as

GenomeZebrafishAnimalsGenomicsMiceRatsevaluationgenome assemblyRattus norvegicusreference

Identifiers

PMID35543507
PMCPMC9236863

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.