Evidence map›Paper›PMID 35543413›Full record

ArticleeLife2022

C/EBPδ-induced epigenetic changes control the dynamic gene transcription of

Saskia-Larissa Jauch-Speer, Marisol Herrera-Rivero, Nadine Ludwig, Bruna Caroline Véras De Carvalho, Leonie Martens, Jonas Wolf, Achmet Imam Chasan, Anika Witten, Birgit Markus, Bernhard Schieffer and 5 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

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  17. S100A8 and S100A9 in Hematologic Malignancies: From Development to Therapy.International journal of molecular sciences · 2023
    Review
  18. CRISPR screening in cardiovascular research.Frontiers in cell and developmental biology · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 3 countries.

Saskia-Larissa Jauch-SpeerInstitute of Immunology, University of Münster, Münster, Germany.ORCID 0000-0002-6739-3051
Marisol Herrera-RiveroDepartment of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany.ORCID 0000-0001-7064-9487
Nadine LudwigDepartment of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Bruna Caroline Véras De CarvalhoInstitute of Immunology, University of Münster, Münster, Germany.
Leonie MartensInstitute of Immunology, University of Münster, Münster, Germany.
Jonas WolfInstitute of Immunology, University of Münster, Münster, Germany.
Achmet Imam ChasanInstitute of Immunology, University of Münster, Münster, Germany.ORCID 0000-0001-5137-6890
Anika WittenDepartment of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany.
Birgit MarkusClinic for Cardiology, Angiology and Internal Intensive Medicine, University Hospital Marburg, Marburg, Germany.
Bernhard SchiefferClinic for Cardiology, Angiology and Internal Intensive Medicine, University Hospital Marburg, Marburg, Germany.
Thomas VoglInstitute of Immunology, University of Münster, Münster, Germany.
Jan RossaintDepartment of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Monika StollDepartment of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany.
Johannes RothInstitute of Immunology, University of Münster, Münster, Germany.ORCID 0000-0001-7035-8348
Olesja FehlerInstitute of Immunology, University of Münster, Münster, Germany.ORCID 0000-0001-6386-7080
University of Münster · DEUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The proinflammatory alarmins S100A8 and S100A9 are among the most abundant proteins in neutrophils and monocytes but are completely silenced after differentiation to macrophages. The molecular mechanisms of the extraordinarily dynamic transcriptional regulation of

Indexed as

Calgranulin ACalgranulin BCCAAT-Enhancer-Binding Protein-deltaEpigenesis, GeneticAlarminsAnimalsMiceTranscription, GeneticAlarminsCalgranulin ACalgranulin BCCAAT-Enhancer-Binding Protein-deltaS100a8 protein, mouseS100A9 protein, mousecalprotectinC/EBPδcell biologyCRISPR/Cas9 screenhumanmonocytesmouseS100A8/A9

Identifiers

PMID35543413
PMCPMC9122501
OpenAlexW4280520403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.