ArticleInternational psychogeriatrics2023
Associations of perceived stress, depressive symptoms, and caregiving with inflammation: a longitudinal study.
Article in International psychogeriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Exploratory Analysis of Inflammatory Biomarkers and Their Association with Psychological Burden in Mexican Informal Caregivers: A Cross-Sectional Study in the Emergency Department.International journal of molecular sciences · 2026Article
- Early functional recovery and clinical risk profiles predict distinct trajectories of post-stroke depression: a one-year longitudinal analysis.BMC neurology · 2025Article
- Relationship between family functioning and psychological distress among young and middle-aged patients with stroke: a moderated mediation model.Scientific reports · 2025Article
- Exploring factors associated with inflammation in stressed workers: a cross-sectional study.BMC public health · 2025Article
- Associations of perceived stress with depression in medical students: the mediating role of rumination and the moderating role of emotional intelligence.Frontiers in psychology · 2025Article
- Perceived Stress and Smartphone Application-Based Addiction Among Chinese Young Adults: The Mediating Role of Psychological Distress and the Moderating Role of Self-Control.Psychology in Russia : state of the art · 2025Article
- Longitudinal associations in dementia family caregivers of ambivalent feelings and disruptive behaviors with C-reactive protein, interleukin-6, and D-dimer.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- A Survey on the Status Quo and Influencing Factors of Health-Related Quality of Life Among Family Caregivers of People with Dementia: A Cross-Sectional Study.International journal of general medicine · 2024Article
- Association between Perceived Stress and Motoric Cognitive Risk Syndrome in an Elderly Population: Rugao Longevity and Aging Study.Dementia and geriatric cognitive disorders · 2024Article
- The role of caregiving in cognitive function and change: The REGARDS study.Psychology and aging · 2023Article
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8 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesHigher inflammation has been linked to poor physical and mental health outcomes, and mortality, but few studies have rigorously examined whether changes in perceived stress and depressive symptoms are associated with increased inflammation within family caregivers and non-caregivers in a longitudinal design.
designLongitudinal Study.
settingREasons for Geographic And Racial Differences in Stroke cohort study.
participantsParticipants included 239 individuals who were not caregivers at baseline but transitioned to providing substantial and sustained caregiving over time. They were initially matched to 241 non-caregiver comparisons on age, sex, race, education, marital status, self-rated health, and history of cardiovascular disease. Blood was drawn at baseline and approximately 9.3 years at follow-up for both groups. MEASUREMENTS: Perceived Stress Scale, Center for Epidemiological Studies-Depression, inflammatory biomarkers, including high-sensitivity C-reactive protein, D dimer, tumor necrosis factor alpha receptor 1, interleukin (IL)-2, IL-6, and IL-10 taken at baseline and follow-up.
resultsAlthough at follow-up, caregivers showed significantly greater worsening in perceived stress and depressive symptoms compared to non-caregivers, there were few significant associations between depressive symptoms or perceived stress on inflammation for either group. Inflammation, however, was associated with multiple demographic and health variables, including age, race, obesity, and use of medications for hypertension and diabetes for caregivers and non-caregivers.
conclusionsThese findings illustrate the complexity of studying the associations between stress, depressive symptoms, and inflammation in older adults, where these associations may depend on demographic, disease, and medication effects. Future studies should examine whether resilience factors may prevent increased inflammation in older caregivers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.