Evidence map›Paper›PMID 35543292›Full record

ArticleHuman brain mapping2022

Physiological instability is linked to mortality in primary central nervous system lymphoma: A case-control fMRI study.

Valter Poltojainen, Janette Kemppainen, Nina Keinänen, Michaela Bode, Juha-Matti Isokangas, Hanne Kuitunen, Juha Nikkinen, Eila Sonkajärvi, Vesa Korhonen, Timo Tuovinen and 8 more

Open access · goldAbstract read
In one paragraph

Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Infra-slow (<0.1 Hz) Modulation of Human Brain Pulsations in Awake and Sleep States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Orexin effect on physiological pulsations of the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Valter PoltojainenOulu Functional Neuroimaging, University of Oulu/Oulu University Hospital, Oulu, Finland.ORCID 0000-0003-1105-1076
Janette KemppainenOulu Functional Neuroimaging, University of Oulu/Oulu University Hospital, Oulu, Finland.
Nina KeinänenDepartment of Anaesthesiology, Oulu University Hospital, Oulu, Finland.
Michaela BodeMedical Imaging, Physics and Technology, University of Oulu, Oulu, Finland.
Juha-Matti IsokangasDepartment of Radiology, Oulu University Hospital, Oulu, Finland.
Hanne KuitunenDepartment of Oncology and Haematology, Oulu University Hospital, Oulu, Finland.
Juha NikkinenMedical Imaging, Physics and Technology, University of Oulu, Oulu, Finland.
Eila SonkajärviDepartment of Anaesthesiology, Oulu University Hospital, Oulu, Finland.
Vesa KorhonenOulu Functional Neuroimaging, University of Oulu/Oulu University Hospital, Oulu, Finland.
Timo TuovinenOulu Functional Neuroimaging, University of Oulu/Oulu University Hospital, Oulu, Finland.
Matti JärveläOulu Functional Neuroimaging, University of Oulu/Oulu University Hospital, Oulu, Finland.
Niko HuotariOulu Functional Neuroimaging, University of Oulu/Oulu University Hospital, Oulu, Finland.
Lauri RaitamaaOulu Functional Neuroimaging, University of Oulu/Oulu University Hospital, Oulu, Finland.ORCID 0000-0003-2884-6510
Janne KananenOulu Functional Neuroimaging, University of Oulu/Oulu University Hospital, Oulu, Finland.ORCID 0000-0001-6831-8056
Tommi KorhonenMedical Research Center, University of Oulu/Oulu University Hospital, Oulu, Finland.
Sami TetriMedical Research Center, University of Oulu/Oulu University Hospital, Oulu, Finland.
Outi KuittinenDepartment of Oncology and Haematology, Oulu University Hospital, Oulu, Finland.
Vesa KiviniemiOulu Functional Neuroimaging, University of Oulu/Oulu University Hospital, Oulu, Finland.ORCID 0000-0003-0184-8524
Oulu University Hospital · FIUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary central nervous system lymphoma (PCNSL) is an aggressive brain disease where lymphocytes invade along perivascular spaces of arteries and veins. The invasion markedly changes (peri)vascular structures but its effect on physiological brain pulsations has not been previously studied. Using physiological magnetic resonance encephalography (MREG

Indexed as

LymphomaMagnetic Resonance ImagingBrainCase-Control StudiesFemaleHumansMaleNeuroimagingbrain pulsationfunctional imaginglymphomamalignancymortality

Identifiers

PMID35543292
PMCPMC9374894
OpenAlexW4280535678

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.