ArticleChemPlusChem2022
Inactivation Kinetics of G-Quadruplex/Hemin Complex and Optimization for More Reliable Catalysis.
Article in ChemPlusChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Rational redesign of high-activity G-quadruplex DNAzyme through flanking and looping of nucleobases.Scientific reports · 2026Article
- A Non-G-Quadruplex Hemin Aptamer Forms a Better Peroxidase Mimicking DNAzyme.Chembiochem : a European journal of chemical biology · 2025Article
- A thermal-activated peroxidase DNAzyme via G-quadruplex nanowires.Communications chemistry · 2025Article
- Self-contained G-quadruplex/hemin DNAzyme: a superior ready-made catalyst for in situ imaging analysis.Nucleic acids research · 2025Article
- CRISPR/Cas14 and G-Quadruplex DNAzyme-Driven Biosensor for Paper-Based Colorimetric Detection of African Swine Fever Virus.ACS sensors · 2024Article
- Optimization and Enhancement of the Peroxidase-like Activity of Hemin in Aqueous Solutions of Sodium Dodecylsulfate.ACS omega · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Reliable catalysis is critical for the synthesis of various chemicals, molecular sensing and biomedicine. G-quadruplex/Hemin (GQH) complex, a peroxidase-mimicking DNAzyme, has been widely used in various publications. However, a concern exists about the unstable kinetics of GQH-catalyzed peroxidation. This work investigates several factors that result in the inactivation of GQH and the signal degradation during long reaction periods, including pH, buffer component, the selection of substrate and the oxidation damage of cofactor. Using colorimetric and fluorescent assays, GQH was found to be highly unstable under basic conditions with 50 % of GQH activity lost within 2 minutes at high H
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Registered trials
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