ArticleRSC advances2018
Gene function prediction based on combining gene ontology hierarchy with multi-instance multi-label learning.
Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene function annotation is the main challenge in the post genome era, which is an important part of the genome annotation. The sequencing of the human genome project produces a whole genome data, providing abundant biological information for the study of gene function annotation. However, to obtain useful knowledge from a large amount of data, a potential strategy is to apply machine learning methods to mine these data and predict gene function. In this study, we improved multi-instance hierarchical clustering by using gene ontology hierarchy to annotate gene function, which combines gene ontology hierarchy with multi-instance multi-label learning frame structure. Then, we used multi-label support vector machine (MLSVM) and multi-label k-nearest neighbor (MLKNN) algorithm to predict the function of gene. Finally, we verified our method in four yeast expression datasets. The performance of the simulated experiments proved that our method is efficient.
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Registered trials
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