Evidence map›Paper›PMID 35542353›Full record

ReviewRSC advances2018

2,3-Dihydroquinazolin-4(1

Mariateresa Badolato, Francesca Aiello, Nouri Neamati

Abstract readReview
In one paragraph

Review in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. RHA/TiOScientific reports · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. 2,3-Dihydroquinazolin-4(1RSC medicinal chemistry · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Synthesis of a Pyrrolo[1,2-Molecules (Basel, Switzerland) · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mariateresa BadolatoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria Ed. Polifunzionale 87036 Arcavacata di Rende CS Italy.ORCID https://orcid.org/0000-0002-5892-9635
Francesca AielloDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria Ed. Polifunzionale 87036 Arcavacata di Rende CS Italy.ORCID https://orcid.org/0000-0001-6846-5582
Nouri NeamatiDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, North Campus Research Complex 1600 Huron Parkway Ann Arbor MI 48109 USA.ORCID https://orcid.org/0000-0003-3291-7131

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

2,3-Dihydroquinazolin-4-one (DHQ) belongs to the class of nitrogen-containing heterocyclic compounds representing a core structural component in various biologically active compounds. In the past decades, several methodologies have been developed for the synthesis of the DHQ framework, especially the 2-substituted derivatives. Unfortunately, multistep syntheses, harsh reaction conditions, and the use of toxic reagents and solvents have limited their full potential as a versatile fragment. Recently, use of green chemistry and alternative strategies are being explored to prepare diverse DHQ derivatives. This fragment is used as a synthon for the preparation of biologically active quinazolinones and as a functional substrate for the synthesis of modified DHQ derivatives exhibiting different biological properties. In this review, we provide a comprehensive assessment of the synthesis and biological evaluations of DHQ derivatives.

Identifiers

PMID35542353
PMCPMC9080947

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.