Evidence map›Paper›PMID 35542044›Full record

ArticleNeurobiology of stress2022

Amygdala and hippocampal subregions mediate outcomes following trauma during typical development: Evidence from high-resolution structural MRI.

Giorgia Picci, Nicholas J Christopher-Hayes, Nathan M Petro, Brittany K Taylor, Jacob A Eastman, Michaela R Frenzel, Yu-Ping Wang, Julia M Stephen, Vince D Calhoun, Tony W Wilson

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Maternal Childhood Maltreatment, Development of Amygdala Volume, and Anxiety Symptoms in Offspring.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Article
  5. Editorial: Neuroprotection Across Generations: Maternal Childhood Trauma and the Developing Amygdala.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Giorgia PicciInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.
Nicholas J Christopher-HayesInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.
Nathan M PetroInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.
Brittany K TaylorInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.
Jacob A EastmanInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.
Michaela R FrenzelInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.
Yu-Ping WangDepartment of Biomedical Engineering, Tulane University, New Orleans, LA, USA.
Julia M StephenMind Research Network, Albuquerque, NM, USA.
Vince D CalhounMind Research Network, Albuquerque, NM, USA.
Tony W WilsonInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.
Boys Town · USCreighton University · USGeorgia Institute of Technology · USMind Research Network · USTulane University · US

Funding

Stress-Induced Aberrations in the Mitochondrial Redox Environment Impact Developing Neural Circuits Supporting Cognitive ControlP20GM144641 · NIGMS · FATHER FLANAGAN'S BOYS' HOME · PI Giorgia Picci · 2022 to 2026
$15.1M
DEVELOPMENTAL MULTIMODAL IMAGING OF NEUROCOGNITIVE DYNAMICS (DEV-MIND)R01MH121101 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2019 to 2023
$5.8M
NIGMS NIH HHS P20 GM144641NIMH NIH HHS R01 MH121101
6 · The paper itself

Abstract

The vast majority of individuals experience trauma within their lifetime. Yet, most people do not go on to develop clinical levels of psychopathology. Recently, studies have highlighted the potential protective effects of having larger amygdala and hippocampal volumes, such that larger volumes may promote adaptive functioning following trauma. However, research has not yet elucidated whether certain subregions of these stress-sensitive structures have specific protective effects. Herein, we examined the mediating effects of amygdala and hippocampal subregions on the relationship between traumatic exposure and concurrent or longitudinal changes in psychiatric symptom levels in typically developing youth (9-15 years of age). Using high-resolution T

Indexed as

AmygdalaAmygdala subnucleiBrain developmentHippocampal subfieldsHippocampusTrauma

Identifiers

PMID35542044
PMCPMC9079354
OpenAlexW4225165382

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.