Evidence map›Paper›PMID 35540700›Full record

ArticleBioinformation2021

Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells.

Chella Perumal Palanisamy, Sivakumar Pethanan, Gopinath Gurulingam Vincent, Karthigeyan Murugesan, Ananthavalli Ramachandran, Ramu Sivanandam, Mani Panagal

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chella Perumal PalanisamyState Key Laboratory of Biobased Material and Green Papermaking, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China.
Sivakumar PethananDepartment of zoology, M R Government arts college, Mannargudi, Tamil Nadu - 614001, India.
Gopinath Gurulingam VincentDepartment of zoology, M R Government arts college, Mannargudi, Tamil Nadu - 614001, India.
Karthigeyan MurugesanDepartment of zoology, M R Government arts college, Mannargudi, Tamil Nadu - 614001, India.
Ananthavalli RamachandranDepartment of zoology, M R Government arts college, Mannargudi, Tamil Nadu - 614001, India.
Ramu SivanandamDepartment of zoology, Arumugam Pillai Seethai Ammal College, Tiruppathur, Tamil Nadu, India.
Mani PanagalDepartment of Biotechnology, Annai College of Arts and Science, Kovilacheri, Kumbakonam, Tamil Nadu - 612503, India.
Qilu University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is of interest to report the chemotherapeutic (drug target based) potential of n-hexane Cayratia trifolia L. (C.trifolia) extract on A2780 cell lines. mRNA and protein expression analysis of the human chemokine receptor (CXCR4) and human epidermal growth factor receptors-2 (HER2) were studied using RT-PCR analysis and western blot analysis. The results show significant cell growth inhibition with minimal IC50 values of 46.25 ± 0.42 micro g/mL against A2780 cell lines. mRNA and protein expression were considerably reduced in

Indexed as

Anti-ovarian cancer activityCayratia trifoliaCXCR4 and HER2 protein expressionMetastatic signalling

Identifiers

PMID35540700
PMCPMC9049100
OpenAlexW4213204075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.