Evidence map›Paper›PMID 35540466›Full record

ArticleRSC advances2018

Discovery of novel inhibitors of RNA silencing suppressor P19 based on virtual screening.

Fan Hu, Rong Lei, Yu-Fang Deng, Jun Wang, Gui-Fen Li, Chao-Nan Wang, Zhi-Hong Li, Shui-Fang Zhu

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Journal of virology · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fan HuCollege of Plant Protection, China Agricultural University Beijing 100193 China zhusf@caiq.gov.cn.ORCID https://orcid.org/0000-0003-0191-1300
Rong LeiInstitute of Plant Quarantine, Chinese Academy of Inspection and Quarantine Beijing 100029 China.ORCID https://orcid.org/0000-0003-0643-6756
Yu-Fang DengCollege of Plant Protection, China Agricultural University Beijing 100193 China zhusf@caiq.gov.cn.
Jun WangInstitute of Plant Quarantine, Chinese Academy of Inspection and Quarantine Beijing 100029 China.
Gui-Fen LiInstitute of Plant Quarantine, Chinese Academy of Inspection and Quarantine Beijing 100029 China.
Chao-Nan WangCollege of Plant Protection, China Agricultural University Beijing 100193 China zhusf@caiq.gov.cn.
Zhi-Hong LiCollege of Plant Protection, China Agricultural University Beijing 100193 China zhusf@caiq.gov.cn.
Shui-Fang ZhuCollege of Plant Protection, China Agricultural University Beijing 100193 China zhusf@caiq.gov.cn.
Chinese Academy of Inspection and Quarantine · CNInstitute of Plant Protection · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To control plant viruses, viral RNA silencing suppressors are important drug targets due to their key roles in interfering antiviral RNA silencing. Here we have presented a strategy, combining virtual and experimental screening, to discover the inhibitors of viral suppressor. By docking 157 026 compounds from a natural product library into P19 model, eighteen candidate compounds were selected. Candidates VS2, VS12, VS14 and VS15 displayed strong binding ability to P19 in the surface plasmon resonance imaging assay with

Identifiers

PMID35540466
PMCPMC9078884
OpenAlexW2792404651

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.