Evidence map›Paper›PMID 35540224›Full record

ArticleRSC advances2019

Drug-likeness of linear pentamidine analogues and their impact on the hERG K

Teresa Żołek, Muge Qile, Paweł Kaźmierczak, Meye Bloothooft, Marcel A G van der Heyden, Dorota Maciejewska

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Teresa ŻołekDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw Banacha 1 02-097 Warsaw Poland tzolek@wum.edu.pl dmaciejewska@wum.edu.pl +48 22 5720643 +48 22 5720643.ORCID https://orcid.org/0000-0002-6781-0329
Muge QileDepartment of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht Utrecht The Netherlands.
Paweł KaźmierczakDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw Banacha 1 02-097 Warsaw Poland tzolek@wum.edu.pl dmaciejewska@wum.edu.pl +48 22 5720643 +48 22 5720643.
Meye BloothooftDepartment of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht Utrecht The Netherlands.
Marcel A G van der HeydenDepartment of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht Utrecht The Netherlands.
Dorota MaciejewskaDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw Banacha 1 02-097 Warsaw Poland tzolek@wum.edu.pl dmaciejewska@wum.edu.pl +48 22 5720643 +48 22 5720643.ORCID https://orcid.org/0000-0002-2114-667X
Medical University of Warsaw · PLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work presents drug-likeness and the cardiotoxicity profiles of six potent pentamidine analogs 1-6 and three new compounds 7-9 as chemotherapeutics for therapy of

Identifiers

PMID35540224
PMCPMC9082326
OpenAlexW2989618183

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.