Evidence map›Paper›PMID 35539858›Full record

ArticleRSC advances2018

High and low molecular weight hyaluronic acid-coated gold nanobipyramids for photothermal therapy.

Shuang Zhao, Ying Tian, Wenfei Liu, Yunyan Su, Yunlei Zhang, Zhaogang Teng, Ying Zhao, Shouju Wang, Guangming Lu, Zhenghong Yu

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Hyaluronan-Metal Gold Nanoparticle Hybrids for Targeted Tumor Cell Therapy.International journal of molecular sciences · 2020
    Article
  7. Article
  8. Review
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Shuang ZhaoDepartment of Medical Oncology, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China m_fish@189.cn.
Ying TianDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China cjr.luguangming@vip.163.com shouju.wang@zoho.com.
Wenfei LiuDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China cjr.luguangming@vip.163.com shouju.wang@zoho.com.
Yunyan SuDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China cjr.luguangming@vip.163.com shouju.wang@zoho.com.
Yunlei ZhangDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China cjr.luguangming@vip.163.com shouju.wang@zoho.com.
Zhaogang TengDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China cjr.luguangming@vip.163.com shouju.wang@zoho.com.ORCID https://orcid.org/0000-0001-8792-764X
Ying ZhaoDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China cjr.luguangming@vip.163.com shouju.wang@zoho.com.
Shouju WangDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China cjr.luguangming@vip.163.com shouju.wang@zoho.com.
Guangming LuDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China cjr.luguangming@vip.163.com shouju.wang@zoho.com.ORCID https://orcid.org/0000-0003-0303-1489
Zhenghong YuDepartment of Medical Oncology, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China m_fish@189.cn.ORCID https://orcid.org/0000-0002-5979-4023
Nanjing General Hospital of Nanjing Military Command · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. It is known that hyaluronic acid (HA) binds CD44 receptors, which are overexpressed on the surface of TNBC cells. To optimize the targeting ability of HA, in this study we coated gold nanobipyramids (GBPs) with high and low molecular weight HA (380 kDa and 102 kDa), named GBPs@h-HA and GBPs@l-HA, respectively. GBPs@l-HA and GBPs@h-HA had excellent stability when dispersed in water and PBS (pH 7.4) for seven days. The HA density was calculated by the ratio of HA to GBPs@l-HA and GBPs@h-HA, which was 13.22 and 4.77, respectively. The two nanoparticles displayed good photostability, which was evaluated by their photothermal performance and similar biocompatibility. Inductively coupled plasma atomic emission spectrometry (ICP-AES) revealed superior cellular uptake of GBPs@h-HA over GBPs@l-HA. Upon 808 nm laser irradiation, the GBPs@h-HA also showed higher therapeutic efficacy than GBPs@l-HA both

Identifiers

PMID35539858
PMCPMC9078663
OpenAlexW2787989660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.