Evidence map›Paper›PMID 35539759›Full record

ArticleRSC advances2018

Determination of uric acid in biological samples by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry and study on pathogenesis of pulmonary arterial hypertension in pulmonary artery endothelium cells.

Qiaozhi Li, Yanli Qiu, Weina Han, Yaqin Zheng, Xiaoying Wang, Dandan Xiao, Min Mao, Qian Li

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 68 citations in OpenAlex.

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  8. Novel LC-MS-TOF method to detect and quantify ascorbic and uric acid simultaneously in different biological matrices.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Qiaozhi LiDepartment of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Harbin Medical University Harbin 150086 P. R. China liqian@ems.hrbmu.edu.cn +86-0451-86699347.
Yanli QiuDepartment of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Harbin Medical University Harbin 150086 P. R. China liqian@ems.hrbmu.edu.cn +86-0451-86699347.
Weina HanDepartment of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University Harbin 150086 P. R. China.
Yaqin ZhengDepartment of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Harbin Medical University Harbin 150086 P. R. China liqian@ems.hrbmu.edu.cn +86-0451-86699347.
Xiaoying WangDepartment of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Harbin Medical University Harbin 150086 P. R. China liqian@ems.hrbmu.edu.cn +86-0451-86699347.
Dandan XiaoDepartment of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Harbin Medical University Harbin 150086 P. R. China liqian@ems.hrbmu.edu.cn +86-0451-86699347.
Min MaoDepartment of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University (Daqing) Daqing 163319 P. R. China.
Qian LiDepartment of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Harbin Medical University Harbin 150086 P. R. China liqian@ems.hrbmu.edu.cn +86-0451-86699347.ORCID https://orcid.org/0000-0002-2393-1938
Harbin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease that can lead to vascular remodelling and hypertension. Clinical diagnosis of PAH is very difficult. Uric acid (UA) can act as a biological marker for screening of PAH in patients. Multiple studies have indicated that reactive oxygen species (ROS) play an important role in the development of PAH. Thus, it is important to study the relationship between UA and ROS based on the pathogenesis of PAH. For monitoring PAH, a high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed to measure the concentration of UA from rat models and pulmonary arterial endothelial cells (PAECs) models, which were induced by monocrotaline (MCT) and hypoxia, respectively. In addition, the treatment groups were treated by

Identifiers

PMID35539759
PMCPMC9082525
OpenAlexW2883165669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.