ArticleRSC advances2018
Development of methodologies for the regioselective synthesis of four series of regioisomer isoxazoles from β-enamino diketones.
Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Synthesis and Biological Evaluation of TDP1 Inhibitors Based on Coumarin and Monoterpenoid Fragments Conjoined by Heterocyclic Moieties.International journal of molecular sciences · 2026Article
- Regioselectivity of the Reaction between β-Enamino Diketones and Methylhydrazine Explained.The Journal of organic chemistry · 2026Article
- Regioselective synthesis of methyl 5-(Beilstein journal of organic chemistry · 2022Article
- Synthesis and Antiprotozoal Profile of 3,4,5-Trisubstituted Isoxazoles.ChemistryOpen · 2021Article
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Authors and funding
7 authors.
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Abstract
Four methodologies are reported for the regioselective synthesis of four series of regioisomer isoxazoles from cyclocondensation of β-enamino diketones and hydroxylamine hydrochloride. Regiochemical control was achieved by varying reaction conditions and substrate structure. The mild reaction conditions used to access 4,5-disubstituted, 3,4-disubtituted, and 3,4,5-trisubstituted regioisomer isoxazoles, as well as the pharmacological and synthetic potential of the products, make these novel methodologies very powerful.
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