ArticleRSC advances2018
Systematic investigation of functional ligands for colloidal stable upconversion nanoparticles.
Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
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Who cites it
21 citing papers in PubMed.
- Surface bioengineering of lanthanide nanoparticles for theranostic applications: From hydrophilic modification to multimodal imaging and therapy.Materials today. Bio · 2026Review
- DNA-Functionalized Nanoparticles for Multicolor Cathodoluminescence Imaging.bioRxiv : the preprint server for biology · 2026Article
- Research Progress on the Application of Upconversion Nanoparticles in Heavy Metal Detection in Foodstuff.Foods (Basel, Switzerland) · 2025Review
- Liraglutide-Conjugated Poly(methyl vinyl ether-ACS applied materials & interfaces · 2025Article
- Understanding shell coating effects to overcome quenching in single anisotropic upconversion nanoparticles.Nature communications · 2025Article
- Review
- Toxicity of Large and Small Surface-Engineered Upconverting Nanoparticles for In Vitro and In Vivo Bioapplications.International journal of molecular sciences · 2024Article
- X-ray excited luminescent nanoparticles for deep photodynamic therapy.RSC advances · 2023Review
- Chemical and Colloidal Stability of Polymer-Coated NaYFInternational journal of molecular sciences · 2023Article
- Spatiotemporally mapping temperature dynamics of lysosomes and mitochondria using cascade organelle-targeting upconversion nanoparticles.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Influence of particle architecture on the photoluminescence properties of silica-coated CdSe core/shell quantum dots.Analytical and bioanalytical chemistry · 2022Article
- Bioconjugates of photon-upconversion nanoparticles for cancer biomarker detection and imaging.Nature protocols · 2022Review
- Engineered lanthanide-doped upconversion nanoparticles for biosensing and bioimaging application.Mikrochimica acta · 2022Review
- On the photostability and luminescence of dye-sensitized upconverting nanoparticles using modified IR820 dyes.Nanoscale advances · 2022Article
- PEG-Neridronate-Modified NaYFACS omega · 2021Article
- Optical tweezers beyond refractive index mismatch using highly doped upconversion nanoparticles.Nature nanotechnology · 2021Article
- Networking State of Ytterbium Ions Probing the Origin of Luminescence Quenching and Activation in Nanocrystals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Highly colloidally stable trimodalScientific reports · 2020Article
- Optically Robust and Biocompatible Mechanosensitive Upconverting Nanoparticles.ACS central science · 2019Article
- Overview of the second super-resolution microscopy session of the joint Asian Biophysics Association/Australian Society for Biophysics meeting.Biophysical reviews · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite intense efforts on surface functionalization to generate hydrophilic upconversion nanoparticles (UCNPs), long-term colloidal stability in physiological buffers remains a major concern. Here we quantitatively investigate the competitive adsorption of phosphate, carboxylic acid and sulphonic acid onto the surface of UCNPs and study their binding strength to identify the best conjugation strategy. To achieve this, we designed and synthesized three di-block copolymers composed of poly(ethylene glycol) methyl ether acrylate and a polymer block bearing phosphate, carboxylic or sulphonic acid anchoring groups prepared by an advanced polymerization technique, Reversible Addition Fragmentation Chain Transfer (RAFT). Analytical tools provide the evidence that phosphate ligands completely replaced all the oleic acid capping molecules on the surface of the UCNPs compared with incomplete ligand exchange by carboxylic and sulphonic acid groups. Meanwhile, simulated quantitative adsorption energy measurements confirmed that among the three functional groups, the calculated adsorption strength for phosphate anchoring ligands is higher which is in good agreement with experimental results regarding the best colloidal stability, especially in phosphate buffer solution. This finding suggests that polymers with multiple anchoring negatively charged phosphate moieties provide excellent colloidal stability for lanthanide ion-doped luminescent nanoparticles for various potential applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.