ArticleRSC advances2018
Cytotoxicity and ER stress-apoptosis gene expression in ZnO nanoparticle exposed THP-1 macrophages: influence of pre-incubation with BSA or palmitic acids complexed to BSA.
Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 15 citations in OpenAlex.
- Assessing cytotoxicity and endoplasmic reticulum stress in human blood-brain barrier cells due to silver and copper oxide nanoparticles.Journal of applied genetics · 2025Article
- Article
- A comparative study of toxicity of TiOInternational journal of nanomedicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a biological microenvironment, biological macromolecules could interact with nanoparticles (NPs) and consequently influence the toxicity of NPs. This study investigated the effects of BSA or palmitic acids complexed to BSA (PA-BSA) on the toxicity of ZnO NPs to THP-1 macrophages. Atomic force microscopy showed the increase of NP heights after pre-incubation with BSA or PA-BSA, but PA-BSA more effectively altered the hydrodynamic size and zeta potential of NPs. Pre-incubation with BSA but not PA-BSA alleviated ZnO NP induced cytotoxicity, and transmission electron microscopy confirmed fewer intrastructural changes after exposure to ZnO NPs pre-incubated with BSA. ZnO NP exposure increased intracellular Zn ions but decreased reactive oxygen species (ROS) and release of soluble monocyte chemotactic protein-1 (sMCP-1), whereas pre-incubation with BSA and PA-BSA induced a different pattern of intracellular Zn ions and modestly increased intracellular ROS. The expression of ER stress marker
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.