Evidence map›Paper›PMID 35539486›Full record

ArticleRSC advances2018

Simple and rapid monitoring of doxorubicin using streptavidin-modified microparticle-based time-resolved fluorescence immunoassay.

Junyu Liang, Zhigao Zhang, Hui Zhao, Shanhe Wan, Xiangming Zhai, Jianwei Zhou, Rongliang Liang, Qiaoting Deng, Yingsong Wu, Guanfeng Lin

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Junyu LiangInstitute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University Guangzhou China wg@smu.edu.cn +86-20-37247604 +86-20-62789355.
Zhigao ZhangInstitute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University Guangzhou China wg@smu.edu.cn +86-20-37247604 +86-20-62789355.
Hui ZhaoDepartment of Plastic and Aesthetic Surgery, Third Affiliated Hospital, Sun Yat-Sen University Guangzhou China.
Shanhe WanGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University Guangzhou China.
Xiangming ZhaiInstitute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University Guangzhou China wg@smu.edu.cn +86-20-37247604 +86-20-62789355.
Jianwei ZhouGuangzhou Darui Biotechnology Co. LTD Guangzhou China.
Rongliang LiangInstitute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University Guangzhou China wg@smu.edu.cn +86-20-37247604 +86-20-62789355.
Qiaoting DengInstitute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University Guangzhou China wg@smu.edu.cn +86-20-37247604 +86-20-62789355.
Yingsong WuInstitute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University Guangzhou China wg@smu.edu.cn +86-20-37247604 +86-20-62789355.
Guanfeng LinExperimental Center of Teaching and Scientific Research, School of Laboratory Medicine and Biotechnology, Southern Medical University Guangzhou China lingf@smu.edu.cn +86-20-37247604 +86-20-62789356.ORCID https://orcid.org/0000-0002-1150-9625
Southern Medical University · CNKai Biotech (South Korea) · KRNational Center for Drug Screening · CNScientific Research Institute of Experimental and Clinical Medicine · RUSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing a simple analytical method suitable for therapeutic drug monitoring in a clinical setting is key to establishing guidelines on accurate dose administration and the advancement of precision medicine. We devised a simple rapid analytical method through the combination of streptavidin-modified microparticles and a time-resolved fluorescence immunoassay for therapeutic drug monitoring. The analytical performance of this method was investigated and validated using clinical samples. By determination of doxorubicin concentration, the proposed assay has shown a satisfactory linear range of detection (3.8-3000 ng mL

Identifiers

PMID35539486
PMCPMC9080157
OpenAlexW2800858073

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.