Evidence map›Paper›PMID 35539373›Full record

ArticleRSC advances2018

Fabrication and characterization of a novel self-assembling micelle based on chitosan cross-linked pectin-doxorubicin conjugates macromolecular pro-drug for targeted cancer therapy.

Zhi-Ping Li, Ming-Chao Jiang, Bo Chen, Pei Gao, Sa Yang, Yu-Feng Liu, Peng-Ju Ye, Dong-Xiu He, Hong-Lin Huang, Cui-Yun Yu

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Zhi-Ping LiHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China Hengyang 421001 China yucuiyunusc@hotmail.com +86 734 8282914 +86 734 8282614.
Ming-Chao JiangHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China Hengyang 421001 China yucuiyunusc@hotmail.com +86 734 8282914 +86 734 8282614.
Bo ChenHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China Hengyang 421001 China yucuiyunusc@hotmail.com +86 734 8282914 +86 734 8282614.
Pei GaoChemistry Department, Eastern Kentucky University Richmond KY USA.
Sa YangHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China Hengyang 421001 China yucuiyunusc@hotmail.com +86 734 8282914 +86 734 8282614.
Yu-Feng LiuHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China Hengyang 421001 China yucuiyunusc@hotmail.com +86 734 8282914 +86 734 8282614.
Peng-Ju YeHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China Hengyang 421001 China yucuiyunusc@hotmail.com +86 734 8282914 +86 734 8282614.
Dong-Xiu HeHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China Hengyang 421001 China yucuiyunusc@hotmail.com +86 734 8282914 +86 734 8282614.ORCID https://orcid.org/0000-0002-2118-529X
Hong-Lin HuangHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China Hengyang 421001 China yucuiyunusc@hotmail.com +86 734 8282914 +86 734 8282614.
Cui-Yun YuHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China Hengyang 421001 China yucuiyunusc@hotmail.com +86 734 8282914 +86 734 8282614.ORCID https://orcid.org/0000-0001-7856-4867
Target (United States) · USEastern Kentucky University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is one of the leading causes of morbidity and mortality worldwide. Doxorubicin is one of the most effective anticancer drugs approved by FDA. However, like all the other anticancer drugs, the efficacy of DOX is associated with high systemic toxicity to healthy tissues. In this study, chitosan cross-linked pectin-doxorubicin conjugates macromolecular pro-drug (CS-PDC-M) was prepared to enhance the therapeutic effects on liver cancer. CS-PDC-M was characterized in terms of size, size distribution, zeta potential, scanning electron microscope (SEM) and drug loading content. The CS-PDC-M achieved prolonged releasing ability was demonstrated by the

Identifiers

PMID35539373
PMCPMC9079223
OpenAlexW2794553220

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.