Evidence map›Paper›PMID 35539087›Full record

ArticleRSC advances2019

A salt-based method to adapt stiffness and biodegradability of porous collagen scaffolds.

Luuk R Versteegden, Marije Sloff, Henk R Hoogenkamp, Michiel W Pot, Jeffrey Pang, Theo G Hafmans, Thijs de Jong, Theo H Smit, Sander C Leeuwenburgh, Egbert Oosterwijk and 3 more

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Potential of Heparan Sulphate Mimetics Integrated Into Collagen Scaffolds for Enhanced Skin Wound Healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 4 countries.

Luuk R VersteegdenDepartment of Biochemistry, Route 280, Radboud Institute for Molecular Life Sciences, Radboud university medical center P. O. Box 9101 6500 HB Nijmegen The Netherlands toin.vankuppevelt@radbodumc.nl.ORCID https://orcid.org/0000-0002-6077-3633
Marije SloffDepartment of Urology, Route 267, Radboud Institute for Molecular Life Sciences, Radboud university medical center P. O. Box 9101 6500 HB Nijmegen The Netherlands.
Henk R HoogenkampDepartment of Biochemistry, Route 280, Radboud Institute for Molecular Life Sciences, Radboud university medical center P. O. Box 9101 6500 HB Nijmegen The Netherlands toin.vankuppevelt@radbodumc.nl.
Michiel W PotDepartment of Biochemistry, Route 280, Radboud Institute for Molecular Life Sciences, Radboud university medical center P. O. Box 9101 6500 HB Nijmegen The Netherlands toin.vankuppevelt@radbodumc.nl.ORCID https://orcid.org/0000-0002-7306-3745
Jeffrey PangDepartment of Biochemistry, Route 280, Radboud Institute for Molecular Life Sciences, Radboud university medical center P. O. Box 9101 6500 HB Nijmegen The Netherlands toin.vankuppevelt@radbodumc.nl.ORCID https://orcid.org/0000-0002-9377-3971
Theo G HafmansDepartment of Biochemistry, Route 280, Radboud Institute for Molecular Life Sciences, Radboud university medical center P. O. Box 9101 6500 HB Nijmegen The Netherlands toin.vankuppevelt@radbodumc.nl.
Thijs de JongDepartment of Medical Biology and Department of Orthopaedics, Amsterdam Movement Sciences, Amsterdam University Medical Centers Meibergdreef 9 1085AZ Amsterdam The Netherlands.ORCID https://orcid.org/0000-0001-9612-2413
Theo H SmitDepartment of Medical Biology and Department of Orthopaedics, Amsterdam Movement Sciences, Amsterdam University Medical Centers Meibergdreef 9 1085AZ Amsterdam The Netherlands.ORCID https://orcid.org/0000-0002-8906-7433
Sander C LeeuwenburghDepartment of Dentistry, Route 309, Radboud university medical center P. O. Box 9101 6500 HB Nijmegen The Netherlands.ORCID https://orcid.org/0000-0003-1471-6133
Egbert OosterwijkDepartment of Urology, Route 267, Radboud Institute for Molecular Life Sciences, Radboud university medical center P. O. Box 9101 6500 HB Nijmegen The Netherlands.
Wout F FeitzDepartment of Urology, Route 267, Radboud Institute for Molecular Life Sciences, Radboud university medical center P. O. Box 9101 6500 HB Nijmegen The Netherlands.
Willeke F DaamenDepartment of Biochemistry, Route 280, Radboud Institute for Molecular Life Sciences, Radboud university medical center P. O. Box 9101 6500 HB Nijmegen The Netherlands toin.vankuppevelt@radbodumc.nl.ORCID https://orcid.org/0000-0003-3155-3030
Toin H van KuppeveltDepartment of Biochemistry, Route 280, Radboud Institute for Molecular Life Sciences, Radboud university medical center P. O. Box 9101 6500 HB Nijmegen The Netherlands toin.vankuppevelt@radbodumc.nl.ORCID https://orcid.org/0000-0002-7028-6783
Radboud University Nijmegen · NLDepartment of Medical Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type I collagen scaffolds for tissue reconstruction often have impaired mechanical characteristics such as limited stiffness and lack of strength. In this study, a new technique is presented to fine-tune stiffness and biodegradability of collagen scaffolds by treatment with concentrated salt solutions. Collagen scaffolds were prepared by a casting, freezing and lyophilization process. Scaffolds were treated with 90% saturated salt solutions, the salts taken from the Hofmeister series, followed by chemical crosslinking. Treatment with salts consisting of a divalent cation in combination with a monovalent anion,

Identifiers

PMID35539087
PMCPMC9075161
OpenAlexW2985217678

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.