Evidence map›Paper›PMID 35539066›Full record

ArticleRSC advances2019

An enzyme-free FRET nanoprobe for ultrasensitive ketamine detection based on ATP-fueled target recycling.

Hong Chen, Yun Zou, Xue Jiang, Fangqi Cao, Wenbin Liu

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hong ChenShanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology 803 Zhongshan North 1st Road Shanghai 200083 P. R. China wbliu1981@163.com +86-21-22028361 +86-21-22028361.
Yun ZouShanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology 803 Zhongshan North 1st Road Shanghai 200083 P. R. China wbliu1981@163.com +86-21-22028361 +86-21-22028361.
Xue JiangShanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology 803 Zhongshan North 1st Road Shanghai 200083 P. R. China wbliu1981@163.com +86-21-22028361 +86-21-22028361.
Fangqi CaoShanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology 803 Zhongshan North 1st Road Shanghai 200083 P. R. China wbliu1981@163.com +86-21-22028361 +86-21-22028361.
Wenbin LiuShanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology 803 Zhongshan North 1st Road Shanghai 200083 P. R. China wbliu1981@163.com +86-21-22028361 +86-21-22028361.ORCID https://orcid.org/0000-0003-4912-6328

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ketamine is a commonly abused drug due to its stimulant, dissociative and hallucinogenic effects. An overdose of ketamine has been found to cause a variety of side effects. Therefore, the identification and quantification of ketamine are of significant importance for clinical purposes and drug seizing. However, conventional methods for ketamine detection possess some disadvantages such as sophisticated procedures, expensive instruments and low sensitivity. Herein, we develop a novel fluorescent nanoprobe for ultrasensitive ketamine detection with signal amplification based on Adenosine Triphosphate (ATP)-fueled target recycling and FRET (fluorescence resonance energy transfer) occurring between the FAM (Fluorescein, tagged with Y-shape DNA) and AuNPs. Based on the combination of FRET and signals circle amplification, the gold nanospheres functionalized with Y-motif DNA (Y@AuNPs) nanoprobe was utilized for effective ketamine detection with the limit of detection (LOD) down to 3 pg mL

Identifiers

PMID35539066
PMCPMC9075121
OpenAlexW2983997269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.