Evidence map›Paper›PMID 35538929›Full record

ArticleFrontiers in network physiology2022

The Mind After Midnight: Nocturnal Wakefulness, Behavioral Dysregulation, and Psychopathology.

Andrew S Tubbs, Fabian-Xosé Fernandez, Michael A Grandner, Michael L Perlis, Elizabeth B Klerman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in network physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  16. Nightmares and insomnia within the acute aftermath of trauma prospectively predict suicidal ideation.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  17. Online Social Networking as a Social Zeitgeber.Current psychiatry reports · 2025
    Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Andrew S TubbsSleep and Health Research Program, Department of Psychiatry, University of Arizona College of Medicine-Tucson, Tucson, AZ, United States.ORCID 0000-0003-3799-5972
Fabian-Xosé FernandezDepartment of Psychology, Evelyn F Mcknight Brain Institute, University of Arizona, Tucson, AZ, United States.ORCID 0000-0002-4288-5383
Michael A GrandnerSleep and Health Research Program, Department of Psychiatry, University of Arizona College of Medicine-Tucson, Tucson, AZ, United States.ORCID 0000-0002-4626-754X
Michael L PerlisDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.ORCID 0000-0002-6806-759X
Elizabeth B KlermanDepartment of Neurology, Division of Sleep Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0002-7402-3171
University of Arizona · USHarvard University · USUniversity of Pennsylvania · US

Funding

The roles of NK3RMnPO and KNDy neurons in vasomotor symptoms, sleep, and cognition in E2 depleted mice.U54AG062322 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Elizabeth B. Klerman · 2020 to 2026
$13.7M
Using Sleep Health to Optimize Smoking Cessation Treatment Response in HIV-Positive AdultsR01DA051321 · NIDA · UNIVERSITY OF ARIZONA · PI FANTRY, LORI E, GRANDNER, MICHAEL A · 2020 to 2024
$4.1M
Sleep and Cardiometabolic Health Disparities at the US/Mexico Border: The Nogales Cardiometabolic Health and Sleep (NoCHeS) StudyR01MD011600 · NIMHD · UNIVERSITY OF ARIZONA · PI GRANDNER, MICHAEL A · 2018 to 2022
$4.1M
Testing Effects of Melatonin on Uterine Contractions in WomenR01HD107064 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI KLERMAN, ELIZABETH B. · 2022 to 2025
$3.0M
Three Approaches to Maintenance Therapy for Chronic Insomnia in Older AdultsR01AG054521 · NIA · UNIVERSITY OF PENNSYLVANIA · PI PERLIS, MICHAEL LLOYD · 2018 to 2021
$2.5M
Sleep Duration Required to Restore Performance during Chronic Sleep RestrictionK24HL105664 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI KLERMAN, ELIZABETH B. · 2010 to 2019
$1.8M
Behavioral Sleep Medicine: Training in Sleep and AgingK24AG055602 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Michael Lloyd Perlis · 2017 to 2026
$1.6M
Treatment of Restless Legs Symptoms with Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD: A Pilot Double-blind, Randomized Clinical TrialR21DA052861 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI WINKELMAN, JOHN W · 2021 to 2022
$462k
NHLBI NIH HHS K24 HL105664NIA NIH HHS K24 AG055602NIA NIH HHS R01 AG054521NIA NIH HHS U54 AG062322NICHD NIH HHS R01 HD107064NIDA NIH HHS R01 DA051321NIDA NIH HHS R21 DA052861NIMHD NIH HHS R01 MD011600
6 · The paper itself

Abstract

Sufficient sleep with minimal interruption during the circadian/biological night supports daytime cognition and emotional regulation. Conversely, disrupted sleep involving significant nocturnal wakefulness leads to cognitive and behavioral dysregulation. Most studies to-date have examined how fragmented or insufficient sleep affects next-day functioning, but recent work highlights changes in cognition and behavior that occur when someone is awake during the night. This review summarizes the evidence for day-night alterations in maladaptive behaviors, including suicide, violent crime, and substance use, and examines how mood, reward processing, and executive function differ during nocturnal wakefulness. Based on this evidence, we propose the

Indexed as

behavioral dysregulationcircadian rhythmsmental healthnocturnal wakefulnesspsychopathologysleepsubstance abusesuicide

Identifiers

PMID35538929
PMCPMC9083440
OpenAlexW4214924637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.