Evidence map›Paper›PMID 35538507›Full record

ArticleJournal of eating disorders2022

Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocol.

Stuart B Murray, Tomislav D Zbozinek, Michelle Craske, Reza Tadayonnejad, Michael Strober, Ausaf A Bari, John P O'Doherty, Jamie D Feusner

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of eating disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05531604 (Appetitive Conditioning in Anorexia Nervosa), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05531604 active not recruitingnot on this map

Appetitive Conditioning in Anorexia Nervosa: Neural, Physiological, and Behavioral Mechanisms

TypeobservationalSponsorCentre for Addiction and Mental HealthRan2022 to 2026Enrolled90ConditionsAnorexia NervosaArmsappetitive conditioning
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Stuart B MurrayDepartment of Psychiatry and Behavioral Sciences, University of Southern California, 2250 Alcazar Street, Los Angeles, CA, 90033, USA. drstuarymurray@gmail.com.ORCID http://orcid.org/0000-0002-5588-2915
Tomislav D ZbozinekDivision of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, USA.
Michelle CraskeDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Reza TadayonnejadDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Michael StroberDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Ausaf A BariDepartment of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, USA.
John P O'DohertyDivision of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, USA.
Jamie D FeusnerDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USCalifornia Institute of Technology · USCentre for Addiction and Mental Health · CAUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnorexia nervosa (AN) is a chronic and disabling psychiatric condition characterized by low hedonic drive towards food, and is thought to be inclusive of altered dimensions of reward processing. Whether there exists a fundamental aberrancy in the capacity to acquire and maintain de novo hedonic associations-a critical component of hedonic responding-has never been studied in AN.

methodsThis multi-modal study will employ a 2-day Pavlovian appetitive conditioning paradigm to interrogate the (1) acquisition, (2) extinction, (3) spontaneous recovery and (4) reinstatement of appetitive learning in adolescents and young adults with AN. Participants will be 30 currently ill, underweight individuals with AN; 30 weight-restored individuals with AN; and 30 age-matched healthy controls, all aged 12-22 years. All subjects will undergo clinical assessment, followed by the 2-day appetitive conditioning task during which fMRI, pupillometry, heart rate deceleration, and subjective ratings will be acquired. DISCUSSION: This study will be the first to interrogate appetitive conditioning in AN-a disorder characterized by altered hedonic responding to food. Results will help establish objective biomarkers of appetitive conditioning in AN and lay the groundwork for developing novel lines of treatment for AN and other psychiatric disorders involving diminished ability to experience pleasure and reward.

trial registrationPending. INTENDED REGISTRY: Clinicaltrials.gov.

Indexed as

Anorexia nervosaAppetitive conditioningEating disordersfMRIReward

Identifiers

PMID35538507
PMCPMC9092702
OpenAlexW4229454049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.