ArticleMolecular psychiatry2022
Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants.
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 38 citations in OpenAlex.
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- Individual and neighborhood socioeconomic inequality and the risk of dementia: A 14-year follow-up study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Life course adiposity and risk of incident osteoporosis: a prospective cohort study from the UK Biobank.Frontiers in endocrinology · 2026Article
- The U-shaped Association between Body Mass Index (BMI) and Cognitive Impairment: Associated Characteristics in Low BMI and High BMI Chinese Adults.Diabetes & metabolism journal · 2026Article
- Insulin resistance (TyG index) and body mass index as metabolic biomarker combined with ApoE genotype to diagnose Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Exploring population and sex-specific disease trajectories for multimorbidities among individuals with overweight or obesity: A retrospective cohort study in UK biobank.Diabetes, obesity & metabolism · 2025Article
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- The causal association between insomnia and cognitive decline: A 2-sample, 2-step multivariable Mendelian randomization study.Medicine · 2025Article
- Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer's disease.Nature communications · 2025Article
- Childhood obesity directly increases age-related macular degeneration risk: the role of physiobiological and immune-metabolic function.Journal of global health · 2025Article
- Obesity and brain volumes: mediation by cardiometabolic and inflammatory measures.Stroke and vascular neurology · 2025Article
- The inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression.Science advances · 2025Article
- Federated learning with multi-cohort real-world data for predicting the progression from mild cognitive impairment to Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Plasma GFAP, NfL, and p-tau181 levels as early biomarkers of dementia in Chinese adults: Shenzhen community cohort study.Aging clinical and experimental research · 2025Article
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
Cohort studies report inconsistent associations between body mass index (BMI) and all-cause incident dementia. Furthermore, evidence on fat distribution and body composition measures are scarce and few studies estimated the association between early life adiposity and dementia risk. Here, we included 322,336 participants from UK biobank to investigate the longitudinal association between life course adiposity and risk of all-cause incident dementia and to explore the underlying mechanisms driven by metabolites, inflammatory cells and brain structures. Among the 322,336 individuals (mean (SD) age, 62.24 (5.41) years; 53.9% women) in the study, during a median 8.74 years of follow-up, 5083 all-cause incident dementia events occurred. The risk of dementia was 22% higher with plumper childhood body size (p < 0.001). A strong U-shaped association was observed between adult BMI and dementia. More fat and less fat-free mass distribution on arms were associated with a higher risk of dementia. Interestingly, similar U-shaped associations were found between BMI and four metabolites (i.e., 3-hydroxybutrate, acetone, citrate and polyunsaturated fatty acids), four inflammatory cells (i.e., neutrophil, lymphocyte, monocyte and leukocyte) and abnormalities in brain structure that were also related to dementia. The findings that adiposity is associated with metabolites, inflammatory cells and abnormalities in brain structure that were related to dementia risk might provide clues to underlying biological mechanisms. Interventions to prevent dementia should begin early in life and include not only BMI control but fat distribution and body composition.
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