Evidence map›Paper›PMID 35538189›Full record

ReviewDrug delivery and translational research2022

Transdermal delivery for gene therapy.

Parbeen Singh, I'jaaz Muhammad, Nicole E Nelson, Khanh T M Tran, Tra Vinikoor, Meysam T Chorsi, Ethan D'Orio, Thanh D Nguyen

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Drug delivery and translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
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  5. Review
  6. Article
  7. Article
  8. Review
  9. Low-Frequency Sonophoresis: A Promising Strategy for Enhanced Transdermal Delivery.Advances in pharmacological and pharmaceutical sciences · 2024
    Review
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Parbeen Singh *Department of Mechanical Engineering, University of Connecticut, Storrs, USA.
I'jaaz Muhammad *Department of Biomedical Engineering, University of Connecticut, Storrs, USA.
Nicole E NelsonDepartment of Biomedical Engineering, University of Connecticut, Storrs, USA.
Khanh T M TranDepartment of Biomedical Engineering, University of Connecticut, Storrs, USA.
Tra VinikoorDepartment of Biomedical Engineering, University of Connecticut, Storrs, USA.
Meysam T ChorsiDepartment of Mechanical Engineering, University of Connecticut, Storrs, USA.
Ethan D'OrioDepartment of Biomedical Engineering, University of Connecticut, Storrs, USA.
Thanh D NguyenDepartment of Mechanical Engineering, University of Connecticut, Storrs, USA. nguyentd@uconn.edu.ORCID 0000-0003-0813-4807
University of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene therapy is a critical constituent of treatment approaches for genetic diseases and has gained tremendous attention. Treating and preventing diseases at the genetic level using genetic materials such as DNA or RNAs could be a new avenue in medicine. However, delivering genes is always a challenge as these molecules are sensitive to various enzymes inside the body, often produce systemic toxicity, and suffer from off-targeting problems. In this regard, transdermal delivery has emerged as an appealing approach to enable a high efficiency and low toxicity of genetic medicines. This review systematically summarizes outstanding transdermal gene delivery methods for applications in skin cancer treatment, vaccination, wound healing, and other therapies.

Indexed as

Drug Delivery SystemsNeedlesAdministration, CutaneousGenetic TherapySkinDNAGene therapyMicroneedlesmiRNAmRNAsiRNATransdermal delivery

Identifiers

PMID35538189
PMCPMC9089295
OpenAlexW4280651069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.