ArticleScientific reports2022
The differences in clinical characteristics and natural history between essential tremor and essential tremor plus.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Epidemiology and Treatment of Patients with Essential Tremor: A Retrospective Cohort Analysis in the United Kingdom.Neuroepidemiology · 2026Article
- Sleep Disturbances and Their Correlates in Essential Tremor and Essential Tremor Plus: A Questionnaire-Based Case-Control Study.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- Natural disease progression vs. DBS-related worsening in essential tremor.medRxiv : the preprint server for health sciences · 2025Article
- Pathophysiological Role of Primary Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Magnetic resonance-guided focused ultrasound thalamotomy as a viable option for essential tremor after deep brain stimulation explantation: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Determinants of clinical and neurophysiological features in essential tremor and essential tremor plus.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Epidemiology and treatment patterns of essential tremor: a retrospective cohort analysis in Germany.Frontiers in neurology · 2025Article
- Polysomnographic Evaluation of Sleep Disorders in Essential Tremor and Essential Tremor Plus: A Comparison With Healthy Controls.Journal of movement disorders · 2025Article
- Essential Tremor and Essential Tremor Plus Are Essentially Similar Electrophysiologically.Movement disorders clinical practice · 2024Article
- Treatment patterns in essential tremor: Real-world evidence from a United Kingdom and France primary care database.European journal of neurology · 2024Article
- Combined cortical thickness and blink reflex recovery cycle to differentiate essential tremor with and without resting tremor.Frontiers in neurology · 2024Article
- Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China.Aging and disease · 2023Article
- Diagnosis Versus Classification of Essential Tremor: A Research Perspective.Journal of movement disorders · 2023Article
- A structural magnetic resonance imaging review of clinical motor outcomes from deep brain stimulation in movement disorders.Brain communications · 2023Review
- Clinical correlates of "pure" essential tremor: the TITAN study.Frontiers in neurology · 2023Article
- Cerebellar voxel-based morphometry in essential tremor.Journal of neurology · 2022Article
- Epidemiologic Disparities and Challenges in Non-parkinsonian Tremor Disorders Research: A Scoping Review Emphasizing the Indian Context.Annals of Indian Academy of NeurologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diverse clinical manifestation of essential tremor (ET) has led to the question whether the different phenotypes may affect the clinical outcome and progression. This study aimed to estimate the clinical characteristics and natural history of ET and ET-plus. A total of 221 patients with ET were included, 117 (52.9%) reclassified as ET and 104 (47.1%) as ET-plus. Patients with ET-plus were significantly older in age at onset (P < 0.001); had a higher frequency of cranial tremors (P < 0.001), neurological comorbidities (P < 0.001) and psychiatric comorbidities (P = 0.025); more tremor progression (P < 0.001); and poorer response to medical treatment (P < 0.001) compared to ET patients. Regression analysis revealed that late-onset tremor (OR 11.02, 95% CI 2.79-43.53), neurological comorbidities (OR 3.38, 95% CI 1.56-7.31), psychiatric comorbidities (OR 4.29, 95% CI 1.48-12.44), cranial tremors (OR 2.10, 95% CI 1.02-4.30), and poor response to medical treatment (OR 3.67, 95% CI 1.87-7.19) were associated with ET-plus diagnosis. ET and ET-plus differ in the age of onset, tremor distribution, comorbidities, treatment response rate, and progression. Identifying the ET phenotypes may increase the clinical value in therapeutic strategies and clinical research in the future.
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