Evidence map›Paper›PMID 35538149›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2022

X-linked genes exhibit miR6891-5p-regulated skewing in Sjögren's syndrome.

Teressa M Shaw, Wei Zhang, Sara S McCoy, Adam Pagenkopf, Diana M Carp, Shivani Garg, Maxwell H Parker, Xueer Qiu, Robert H Scofield, Jacques Galipeau and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Long Non-Coding RNAs in Sjögren's Disease.International journal of molecular sciences · 2024
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Teressa M ShawDepartment of Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Wei ZhangDepartment of Medicine, University of California, San Diego, CA, USA.
Sara S McCoyDivision of Rheumatology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Adam PagenkopfDepartment of Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Diana M CarpDepartment of Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Shivani GargDivision of Rheumatology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Maxwell H ParkerDivision of Rheumatology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Xueer QiuDepartment of Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Robert H ScofieldDepartment of Pathology and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Jacques GalipeauDepartment of Medicine, Carbone Comprehensive Cancer Center, University of Wisconsin, WI, Madison, USA.
Yun LiangDepartment of Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, WI, 53706, USA. liang95@wisc.edu.ORCID 0000-0003-3043-5139
University of Wisconsin–Madison · USBristol-Myers Squibb (Germany) · DEUniversity of Oklahoma Health Sciences Center · USUniversity of Wisconsin Carbone Cancer Center · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Institutional Career Development CoreKL2TR002374 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Bo Liu, Marin Leigh Schweizer · 2017 to 2026
$9.7M
Cytokine primed autologous Mesenchymal Stromal Cells for therapy of colitis.R01DK109508 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI GALIPEAU, JACQUES · 2016 to 2019
$2.1M
The Role of VGLL3 in Sexually Dimorphic Interferon-Driven InflammationK01AR073340 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI LIANG, YUN · 2018 to 2023
$427k
NCATS NIH HHS KL2 TR002374NCATS NIH HHS UL1 TR002373NIAMS NIH HHS K01 AR073340NIDDK NIH HHS R01 DK109508
6 · The paper itself

Abstract

Many autoimmune diseases exhibit a strikingly increased prevalence in females, with primary Sjögren's syndrome (pSS) being the most female-predominant example. However, the molecular basis underlying the female-bias in pSS remains elusive. To address this knowledge gap, we performed genome-wide, allele-specific profiling of minor salivary gland-derived mesenchymal stromal cells (MSCs) from pSS patients and control subjects, and detected major differences in the regulation of X-linked genes. In control female MSCs, X-linked genes were expressed from both paternal and maternal X chromosomes with a median paternal ratio of ~ 0.5. However, in pSS female MSCs, X-linked genes exhibited preferential expression from one of the two X chromosomes. Concomitantly, pSS MSCs showed decrease in XIST levels and reorganization of H3K27me3

Indexed as

Genes, X-LinkedMicroRNAsSjogren's SyndromeFemaleHistonesHumansHistonesMicroRNAsMIRN6891 microRNA, humanNoncoding RNASalivary gland mesenchymal stromal cellsSjögren’s syndrome pathogenesisX-linked gene expression

Identifiers

PMID35538149
PMCPMC9420820
OpenAlexW4229439421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.