Evidence map›Paper›PMID 35538060›Full record

SynthesisNature communications2022

Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy.

Smriti Prasad, Erkan Kalafat, Helena Blakeway, Rosemary Townsend, Pat O'Brien, Edward Morris, Tim Draycott, Shakila Thangaratinam, Kirsty Le Doare, Shamez Ladhani and 4 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed, 12 pooled it
51.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 12 syntheses or guidelines pooled it, 287 citations in OpenAlex.

  1. Pooled it
  2. Fetal death: Expert consensus of the French College of Obstetricians and Gynecologists.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Neonatal and maternal outcomes of mRNA versus Non-mRNA COVID-19 vaccines in pregnant patients: a systematic review and meta-analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024
    Pooled it
  7. Pooled it
  8. Pooled it
  9. The dose- and time-dependent effectiveness and safety associated with COVID-19 vaccination during pregnancy: a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
    Pooled it
  10. Pooled it
  11. Effect of COVID-19 vaccination on the outcome ofFrontiers in public health · 2023
    Pooled it
  12. Pooled it
  13. Trial
  14. Article
  15. Review
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Article

99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Smriti Prasad *Fetal Medicine Unit, St George's Hospital, St George's University of London, London, UK.
Erkan Kalafat *Department of Statistics, Faculty of Arts and Sciences, Middle East Technical University, Ankara, Turkey.
Helena BlakewayFetal Medicine Unit, St George's Hospital, St George's University of London, London, UK.ORCID 0000-0003-4000-8923
Rosemary TownsendUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Pat O'BrienThe Royal College of Obstetricians and Gynaecologists, London, UK.
Edward MorrisThe Royal College of Obstetricians and Gynaecologists, London, UK.
Tim DraycottThe Royal College of Obstetricians and Gynaecologists, London, UK.
Shakila ThangaratinamInstitute of Metabolism and Systems Research, WHO Collaborating Centre for Women's Health, University of Birmingham, Birmingham, UK.
Kirsty Le DoarePaediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St George's University of London, London, UK.
Shamez LadhaniImmunisation and Countermeasures Division, Public Health England, England, UK.
Peter von DadelszenInstitute of Women and Children's Health, School of Life Course Sciences, King's College London, London, UK.
Laura A MageeInstitute of Women and Children's Health, School of Life Course Sciences, King's College London, London, UK.
Paul HeathPaediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St George's University of London, London, UK.
Asma KhalilFetal Medicine Unit, St George's Hospital, St George's University of London, London, UK. akhalil@sgul.ac.uk.ORCID 0000-0003-2802-7670
St George's, University of London · GBRoyal College of Obstetricians and Gynaecologists · GBKing's College London · GBKoç University · TRPublic Health England · GBUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Safety and effectiveness of COVID-19 vaccines during pregnancy is a particular concern affecting vaccination uptake by this vulnerable group. Here we evaluated evidence from 23 studies including 117,552 COVID-19 vaccinated pregnant people, almost exclusively with mRNA vaccines. We show that the effectiveness of mRNA vaccination against RT-PCR confirmed SARS-CoV-2 infection 7 days after second dose was 89·5% (95% CI 69·0-96·4%, 18,828 vaccinated pregnant people, I

Indexed as

COVID-19Premature BirthCOVID-19 VaccinesFemaleHumansInfant, NewbornIntensive Care Units, NeonatalPlacentaPregnancyRNA, MessengerSARS-CoV-2StillbirthVaccinationCOVID-19 VaccinesRNA, Messenger

Identifiers

PMID35538060
PMCPMC9090726
OpenAlexW4229452156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.