Potential pharmacologic interventions targeting TLR signaling in placental malaria.

Francis M Kobia, Kaushik Maiti, Moses M Obimbo, Roger Smith, Jesse Gitaka

Open access · greenAbstract readReview

In one paragraph

Review in Trends in parasitology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 47% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Francis M KobiaDirectorate of Research and Innovation, Mount Kenya University, P.O. Box 342, 01000, Thika, Kenya; Centre for Malaria Elimination, Mount Kenya University, P.O. Box 342, 01000, Thika, Kenya. Electronic address: kobiafrancis@gmail.com.

Kaushik MaitiMothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NSW, Australia.

Moses M ObimboDepartment of Human Anatomy and Physiology, University of Nairobi, Kenya.

Roger SmithMothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NSW, Australia.

Jesse GitakaDirectorate of Research and Innovation, Mount Kenya University, P.O. Box 342, 01000, Thika, Kenya; Centre for Malaria Elimination, Mount Kenya University, P.O. Box 342, 01000, Thika, Kenya. Electronic address: jgitaka@mku.ac.ke.

Hunter Medical Research Institute · AUMount Kenya University · KEUniversity of Nairobi · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complications from placental malaria cause poor pregnancy outcomes, including low birthweight, preterm delivery, and stillbirths. Many of these complications are driven by maternal innate proinflammatory responses to the sequestration of Plasmodium falciparum in the placenta. However, recent studies show that, in reaction to maternal innate immune responses that are detrimental to the fetus, the fetus mounts innate immune counter-responses that ameliorate pregnancy outcomes. Such fetal-maternal conflict in placental malaria has potential for pharmacologic modulation for better pregnancy outcomes. Here, we discuss placental malaria pathogenesis, its complications, and the role of innate immunity and fetal-maternal innate immune conflict in placental malaria. Finally, we discuss pharmacologic immunomodulatory strategies and agents with the potential to improve placental malaria outcomes.

Indexed as

MalariaMalaria, FalciparumPregnancy Complications, ParasiticFemaleHumansInfant, NewbornPlacentaPlasmodium falciparumPregnancyfetal–maternal immune conflictinnate immune responsesplacental malariapregnancy outcomes

Identifiers

PMID35537977

DOI10.1016/j.pt.2022.04.002

PMCPMC7614649

OpenAlexW4229004531

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.