Evidence map›Paper›PMID 35537918›Full record

ArticleJournal of substance abuse treatment2022

Evaluating disparities in prescribing of naloxone after emergency department treatment of opioid overdose.

Scott G Weiner, Aleta D Carroll, Nicholas M Brisbon, Claudia P Rodriguez, Charles Covahey, Erin J Stringfellow, Catherine DiGennaro, Mohammad S Jalali, Sarah E Wakeman

Open access · greenAbstract read
In one paragraph

Article in Journal of substance abuse treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Scott G WeinerDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America. Electronic address: sweiner@bwh.harvard.edu.
Aleta D CarrollMass General Brigham, Somerville, MA, United States of America. Electronic address: adcarroll@partners.org.
Nicholas M BrisbonMass General Brigham, Somerville, MA, United States of America.
Claudia P RodriguezHarvard Medical School, Boston, MA, United States of America; Brigham and Women's Hospital, Boston, MA, United States of America. Electronic address: crodriguez17@bwh.harvard.edu.
Charles CovaheyMass General Brigham, Somerville, MA, United States of America. Electronic address: ccovahey@pchi.partners.org.
Erin J StringfellowHarvard Medical School, Boston, MA, United States of America; MGH Institute for Technology Assessment, Boston, MA, United States of America. Electronic address: estringfellow@mgh.harvard.edu.
Catherine DiGennaroHarvard Medical School, Boston, MA, United States of America; MGH Institute for Technology Assessment, Boston, MA, United States of America. Electronic address: cdigennaro@mgh.harvard.edu.
Mohammad S JalaliHarvard Medical School, Boston, MA, United States of America; MGH Institute for Technology Assessment, Boston, MA, United States of America. Electronic address: msjalali@mgh.harvard.edu.
Sarah E WakemanHarvard Medical School, Boston, MA, United States of America; Massachusetts General Hospital, Boston, MA, United States of America. Electronic address: swakeman@partners.org.
Harvard University · USPolitical Research Associates · USMassachusetts General Hospital · USMGH Institute of Health Professions · US

Funding

Using a Novel Comprehensive Linked Dataset to Determine Early Predictors of Opioid OverdoseR01DA044167 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI WEINER, SCOTT GORDON · 2018 to 2022
$2.6M
NIDA NIH HHS R01 DA044167
6 · The paper itself

Abstract

introductionPatients who initially survive opioid-related overdose are at high risk for subsequent mortality. Our health system aimed to evaluate the presence of disparities in prescribing naloxone following opioid overdose.

methodsThis was a retrospective cohort study of patients seen in our health system, which comprises two academic centers and eight community hospitals. Eligible patients had at least one visit to any of our hospital's emergency departments (EDs) with a diagnosis code indicating opioid-related overdose between May 1, 2018, and April 30, 2021. The primary outcome measure was prescription of nasal naloxone after at least one visit for opioid-related overdose during the study period.

resultsThe health system had 1348 unique patients who presented 1593 times to at least one of the EDs with opioid overdose. Of included patients, 580 (43.2%) received one or more prescriptions for naloxone. The majority (68.9%, n = 925) were male. For race/ethnicity, 74.5% (1000) were Non-Hispanic White, 8.0% (n = 108) were Non-Hispanic Black, and 13.0% (n = 175) were Hispanic/Latinx. Compared with the reference age group of 16-24 years, only those 65+ were less likely to receive naloxone (adjusted odds ratio [aOR] 0.41, 95% confidence interval [CI] 0.20-0.84). The study found no difference for gender (male aOR 1.23, 95% CI 0.97-1.57 compared to female). Hispanic/Latinx patients were more likely to receive a prescription when compared to Non-Hispanic White patients (aOR 1.72, 95% CI 1.22-2.44), while no difference occurred between Non-Hispanic Black compared to Non-Hispanic White patients (aOR 1.31, 95% CI 0.87-1.98).

conclusionsNaloxone prescribing after overdose in our system was suboptimal, with fewer than half of patients with an overdose diagnosis code receiving this lifesaving and evidence-based intervention. Patients who were Hispanic/Latinx were more likely to receive naloxone than other race and ethnicity groups, and patients who were older were less likely to receive it. Health systems need ongoing equity-informed implementation of programs to expand access to naloxone to all patients at risk.

Indexed as

Drug OverdoseOpiate OverdoseOpioid-Related DisordersAdolescentAdultAnalgesics, OpioidEmergency Service, HospitalFemaleHumansMaleNaloxoneNarcotic AntagonistsRetrospective StudiesYoung AdultAnalgesics, OpioidNaloxoneNarcotic AntagonistsDisparitiesNaloxoneOpioid overdose

Identifiers

PMID35537918
PMCPMC9187615
OpenAlexW4225156035

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.