ArticleJournal of neurology, neurosurgery, and psychiatry2022
Discrepancy between disability and reported well-being after traumatic brain injury.
Article in Journal of neurology, neurosurgery, and psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guidelines for Neuroprognostication in Critically ill Adults with Acute Ischemic Stroke.Neurocritical care · 2026Guideline
- Quality of life after tranexamic acid in subarachnoid hemorrhage: post-hoc analysis of the ULTRA trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Trial
- Task Practice With and Without Aerobic Exercise Improves Health-related Quality of Life and Social Participation Post-stroke: A Randomized Clinical Trial.Neurorehabilitation and neural repair · 2025Trial
- Patient-and Caregiver-Centered Outcomes in Survivors of Severe Stroke with Respiratory Failure at 6 Months: A Substudy of the SETPOINT2 Trial.Neurocritical care · 2026Article
- Good Recovery, Poor Participation? A Secondary Analysis of the Dissociation Between Global Disability and Real-Life Participation Five Years After Traumatic Brain Injury.Medical sciences (Basel, Switzerland) · 2026Article
- A survey of physicians perceptions of disability outcomes after hypothetical traumatic brain injury.Scientific reports · 2026Article
- Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable.Intensive care medicine · 2026Review
- Assessment of quality of life after traumatic brain injury in adults from Armenia, Georgia, and Moldova using EQ-5D-5L.Scientific reports · 2025Article
- Association Between Disability and Life Satisfaction, Participation, and Psychological Health: A Traumatic Brain Injury Model Systems Study.Neurology · 2025Article
- Health-related quality of life after spontaneous subarachnoid hemorrhage - a prospective cohort study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Delayed Withdrawal of Life-Sustaining Treatment in Disorders of Consciousness: Practical and Theoretical Considerations.Neurocritical care · 2025Review
- Transfusion Thresholds and Neurological Functional Outcome After Acute Brain Injury: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials.Journal of clinical medicine · 2025Review
- Practical approaches to the tasks of preserving autonomy and respecting vulnerability among critically ill adult patients: a narrative review.Critical care science · 2025Review
- Recovery Potential in Patients Who Died After Withdrawal of Life-Sustaining Treatment: A TRACK-TBI Propensity Score Analysis.Journal of neurotrauma · 2024Article
- Influence of health insurance on withdrawal of life sustaining treatment for patients with isolated traumatic brain injury: a retrospective multi-center observational cohort study.Critical care (London, England) · 2024Observational
- Would You Rather: Quantifying Traumatic Brain Injury Survivor Perceptions of Functional Status Through Their Surrogates.Annals of surgery · 2024Article
- Good Health-Related Quality of Life in Older Patients One Year after mTBI despite Incomplete Recovery: An Indication of the Disability Paradox?Journal of clinical medicine · 2024Article
- Tranexamic acid: a narrative review of its current role in perioperative medicine and acute medical bleeding.Frontiers in medicine · 2024Review
- How Severe Is Severe Disability After Traumatic Brain Injury? Response to Sarigul B et al.,Journal of neurotrauma · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFollowing traumatic brain injury (TBI), the clinical focus is often on disability. However, patients' perceptions of well-being can be discordant with their disability level, referred to as the 'disability paradox'. We aimed to examine the relationship between disability and health-related quality of life (HRQoL) following TBI, while taking variation in personal, injury-related and environment factors into account.
methodsWe used data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury study. Disability was assessed 6 months post-injury by the Glasgow Outcome Scale-Extended (GOSE). HRQoL was assessed by the SF-12v2 physical and mental component summary scores and the Quality of Life after Traumatic Brain Injury overall scale. We examined mean total and domain HRQoL scores by GOSE. We quantified variance in HRQoL explained by GOSE, personal, injury-related and environment factors with multivariable regression.
resultsSix-month outcome assessments were completed in 2075 patients, of whom 78% had mild TBI (Glasgow Coma Scale 13-15). Patients with severe disability had higher HRQoL than expected on the basis of GOSE alone, particularly after mild TBI. Up to 50% of patients with severe disability reported HRQoL scores within the normative range. GOSE, personal, injury-related and environment factors explained a limited amount of variance in HRQoL (up to 29%).
conclusionContrary to the idea that discrepancies are unusual, many patients with poor functional outcomes reported well-being that was at or above the boundary considered satisfactory for the normative sample. These findings challenge the idea that satisfactory HRQoL in patients with disability should be described as 'paradoxical' and question common views of what constitutes 'unfavourable' outcome.
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