Evidence map›Paper›PMID 35537723›Full record

ArticleSaudi medical journal2022

Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules.

Saad M Alqahtani, Sultan F Alanesi, Waqas S Mahmood, Yassin M Moustafa, Laila M Moharram, Nawaf F Alharthi, Attiya M Alzahrani, Yousef S Alalawi

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In one paragraph

Article in Saudi medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Saad M AlqahtaniFrom the Department of Surgery (Alqahtani), from ther Department of Community Medicine and Public Health (Mahmood), College of Medicine, Majmaah University, Al-Majmaah; from the Department of Surgery (Alanesi, Alharthi, Alzahrani, Alalawi), from the Department of Radiodiagnostics and Medical Imaging (Moustafa), from the Department of Pathology (Moharram), King Salman Armed Forces Hospital Northwestern Region, Tabuk, Kingdom of Saudi Arabia, and from Azra Naheed Medical College (Mahmood), Superior University, Lahore, Pakistan.
Sultan F AlanesiFrom the Department of Surgery (Alqahtani), from ther Department of Community Medicine and Public Health (Mahmood), College of Medicine, Majmaah University, Al-Majmaah; from the Department of Surgery (Alanesi, Alharthi, Alzahrani, Alalawi), from the Department of Radiodiagnostics and Medical Imaging (Moustafa), from the Department of Pathology (Moharram), King Salman Armed Forces Hospital Northwestern Region, Tabuk, Kingdom of Saudi Arabia, and from Azra Naheed Medical College (Mahmood), Superior University, Lahore, Pakistan.
Waqas S MahmoodFrom the Department of Surgery (Alqahtani), from ther Department of Community Medicine and Public Health (Mahmood), College of Medicine, Majmaah University, Al-Majmaah; from the Department of Surgery (Alanesi, Alharthi, Alzahrani, Alalawi), from the Department of Radiodiagnostics and Medical Imaging (Moustafa), from the Department of Pathology (Moharram), King Salman Armed Forces Hospital Northwestern Region, Tabuk, Kingdom of Saudi Arabia, and from Azra Naheed Medical College (Mahmood), Superior University, Lahore, Pakistan.
Yassin M MoustafaFrom the Department of Surgery (Alqahtani), from ther Department of Community Medicine and Public Health (Mahmood), College of Medicine, Majmaah University, Al-Majmaah; from the Department of Surgery (Alanesi, Alharthi, Alzahrani, Alalawi), from the Department of Radiodiagnostics and Medical Imaging (Moustafa), from the Department of Pathology (Moharram), King Salman Armed Forces Hospital Northwestern Region, Tabuk, Kingdom of Saudi Arabia, and from Azra Naheed Medical College (Mahmood), Superior University, Lahore, Pakistan.
Laila M MoharramFrom the Department of Surgery (Alqahtani), from ther Department of Community Medicine and Public Health (Mahmood), College of Medicine, Majmaah University, Al-Majmaah; from the Department of Surgery (Alanesi, Alharthi, Alzahrani, Alalawi), from the Department of Radiodiagnostics and Medical Imaging (Moustafa), from the Department of Pathology (Moharram), King Salman Armed Forces Hospital Northwestern Region, Tabuk, Kingdom of Saudi Arabia, and from Azra Naheed Medical College (Mahmood), Superior University, Lahore, Pakistan.
Nawaf F AlharthiFrom the Department of Surgery (Alqahtani), from ther Department of Community Medicine and Public Health (Mahmood), College of Medicine, Majmaah University, Al-Majmaah; from the Department of Surgery (Alanesi, Alharthi, Alzahrani, Alalawi), from the Department of Radiodiagnostics and Medical Imaging (Moustafa), from the Department of Pathology (Moharram), King Salman Armed Forces Hospital Northwestern Region, Tabuk, Kingdom of Saudi Arabia, and from Azra Naheed Medical College (Mahmood), Superior University, Lahore, Pakistan.
Attiya M AlzahraniFrom the Department of Surgery (Alqahtani), from ther Department of Community Medicine and Public Health (Mahmood), College of Medicine, Majmaah University, Al-Majmaah; from the Department of Surgery (Alanesi, Alharthi, Alzahrani, Alalawi), from the Department of Radiodiagnostics and Medical Imaging (Moustafa), from the Department of Pathology (Moharram), King Salman Armed Forces Hospital Northwestern Region, Tabuk, Kingdom of Saudi Arabia, and from Azra Naheed Medical College (Mahmood), Superior University, Lahore, Pakistan.
Yousef S AlalawiFrom the Department of Surgery (Alqahtani), from ther Department of Community Medicine and Public Health (Mahmood), College of Medicine, Majmaah University, Al-Majmaah; from the Department of Surgery (Alanesi, Alharthi, Alzahrani, Alalawi), from the Department of Radiodiagnostics and Medical Imaging (Moustafa), from the Department of Pathology (Moharram), King Salman Armed Forces Hospital Northwestern Region, Tabuk, Kingdom of Saudi Arabia, and from Azra Naheed Medical College (Mahmood), Superior University, Lahore, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo estimate the risk of malignancy in indeterminate thyroid nodules and to determine whether certain clinical or radiological parameters can predict the risk of malignancy.

methodsThis retrospective study enrolled all adult patients (age ≥14 years) with a cytological diagnosis of atypia/follicular lesion of undetermined significance and follicular neoplasm/suspicious for a follicular neoplasm between January 2014 and January 2020. Fifty patients with surgically treated primary thyroid nodules, documented final histological diagnosis, and ultrasound examination records were included. Thyroid nodules were evaluated radiologically using Thyroid Imaging Reporting and Data System introduced by the American College of Radiology (2017).

resultsForty-two (84.0%) female and 8 (16.0%) male patients were enrolled in the study. The malignancy risks were 44.8% for Bethesda III and 28.6% for Bethesda IV. The malignancy risks for the Thyroid Imaging Reporting and Data System categories were 33.3% (TR2), 39.1% (TR3), 35.3% (TR4), and 50% (TR5). No significant associations were observed between age, gender, Bethesda category, and Thyroid Imaging Reporting and Data System and the risk of malignancy.

conclusionNone of the clinical or radiological characteristics evaluated in this study contributed to the cancer risk stratification of thyroid nodules with indeterminate cytology. A prospective multicenter study is needed to better understand cytologically indeterminate thyroid nodules.

Indexed as

Thyroid NeoplasmsThyroid NoduleAdolescentAdultBiopsy, Fine-NeedleFemaleHumansMaleProspective StudiesRetrospective StudiesRisk AssessmentUltrasonographyAmerican College of Radiology Thyroid Imaging Reporting and Data SystemBethesda categories III and IVcytologically indeterminate thyroid nodules

Identifiers

PMID35537723
PMCPMC9280589

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.