Evidence map›Paper›PMID 35537691›Full record

ArticlePhytotherapy research : PTR2022

Schwarzinicine A inhibits transient receptor potential canonical channels and exhibits overt vasorelaxation effects.

Yin-Ying Mak, Bi-Juin Loong, Paul Millns, Claudia C Bauer, Robin S Bon, Yvonne Mbaki, Fong-Kai Lee, Kuan-Hon Lim, Cin Kong, Sue-Mian Then and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Phytotherapy research : PTR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Yin-Ying MakSchool of Pharmacy, University of Nottingham Malaysia, Semenyih, Malaysia.
Bi-Juin LoongSchool of Pharmacy, University of Nottingham Malaysia, Semenyih, Malaysia.
Paul MillnsSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Claudia C BauerDepartment of Discovery and Translational Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Robin S BonDepartment of Discovery and Translational Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Yvonne MbakiSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Fong-Kai LeeSchool of Pharmacy, University of Nottingham Malaysia, Semenyih, Malaysia.
Kuan-Hon LimSchool of Pharmacy, University of Nottingham Malaysia, Semenyih, Malaysia.
Cin KongSchool of Pharmacy, University of Nottingham Malaysia, Semenyih, Malaysia.
Sue-Mian ThenSchool of Pharmacy, University of Nottingham Malaysia, Semenyih, Malaysia.
Kang-Nee TingSchool of Pharmacy, University of Nottingham Malaysia, Semenyih, Malaysia.ORCID https://orcid.org/0000-0002-7818-3922
University of Nottingham Malaysia Campus · MYUniversity of Leeds · GBUniversity of Nottingham · GB

Funding

British Heart Foundation PG/19/2/34084British Pharmacological Society Schachter awardMalaysia Toray Science Foundation TML-CA/17.195(17/G62)Ministry of Higher Education, Malaysia FRGS/1/2017/SKK10/UNIM/01/1Ministry of Higher Education, Malaysia FRGS/1/2017/STG01/UNIM/02/3University of Nottingham
6 · The paper itself

Abstract

This study investigated the vasorelaxant effects of schwarzinicine A, an alkaloid recently reported from Ficus schwarzii Koord. Regulation of calcium homeostasis in vascular smooth muscle cells (VSMC) is viewed as one of the main mechanisms for controlling blood pressure. L-type voltage-gated calcium channel (VGCC) blockers are commonly used for controlling hypertension. Recently, the transient receptor potential canonical (TRPC) channels were found in blood vessels of different animal species with evidence of their roles in the regulation of vascular contractility. In this study, we studied the mechanism of actions of schwarzinicine A focusing on its regulation of L-type VGCC and TRPC channels. Schwarzinicine A exhibited the highest vasorelaxant effect (123.1%) compared to other calcium channel blockers. It also overtly attenuated calcium-induced contractions of the rat isolated aortae in a calcium-free environment showing its mechanism to inhibit calcium influx. Fluorometric intracellular calcium recordings confirmed its inhibition of hTRPC3-, hTRPC4-, hTRPC5- and hTRPC6-mediated calcium influx into HEK cells with IC

Indexed as

Transient Receptor Potential ChannelsVasodilationAnimalsCalciumCalcium Channel BlockersCalcium Channels, L-TypeRatsVasodilator AgentsCalciumCalcium Channel BlockersCalcium Channels, L-TypeTransient Receptor Potential ChannelsVasodilator Agentscalcium channel blockerFicus schwarziiL-type voltage-gated calcium channelsschwarzinicine ATRPC channelsvasorelaxation

Identifiers

PMID35537691
PMCPMC9544403
OpenAlexW4280610210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.