Evidence map›Paper›PMID 35537596›Full record

ReviewFree radical biology & medicine2022

Screening neuroprotective compounds in herpes-induced Alzheimer's disease cell and 3D tissue models.

Isabella A Silveira, Adam S Mullis, Dana M Cairns, Anna Shevzov-Zebrun, Jordyn Whalen, Alexa Galuppo, Katherine G Walsh, David L Kaplan

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Free radical biology & medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Isabella A SilveiraDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Adam S MullisDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Dana M CairnsDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA; Allen Discovery Center, Tufts University, Medford, MA, 02155, USA.
Anna Shevzov-ZebrunDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Jordyn WhalenDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Alexa GaluppoDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Katherine G WalshDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
David L KaplanDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA; Allen Discovery Center, Tufts University, Medford, MA, 02155, USA. Electronic address: david.kaplan@tufts.edu.
Tufts University · US

Funding

Tissue Engineering Resource Center: TTDP41EB027062 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gordana Vunjak-Novakovic · 2019 to 2026
$12.6M
NIBIB NIH HHS P41 EB027062
6 · The paper itself

Abstract

Alzheimer's Disease (AD) is a neurodegenerative disorder that can cause life-altering and debilitating cognitive decline. AD's etiology is poorly understood, and no disease-modifying therapeutics exist. Here, we describe the use of 2D and 3D tissue culture models of herpesvirus-induced AD, which recapitulate hallmark disease features of plaque formation, gliosis, neuroinflammation, and impaired neuronal signaling, to screen a panel of 21 medications, supplements, and nutraceuticals with purported neuroprotective benefits. This screen identified green tea catechins and resveratrol as having strong anti-plaque properties, functional neuroprotective benefits, and minimal neurotoxicity, providing support for their further investigation as AD preventives and therapies. Two other candidates, citicoline and metformin, reduced plaque formation and were minimally toxic, but did not protect against virus-induced impairments in neuronal signaling. This study establishes a simple platform for rapidly screening and characterizing AD compounds of interest in 2D and 3D human cortical tissue models representing physiologically relevant disease features.

Indexed as

Alzheimer DiseaseCognitive DysfunctionNeuroprotective AgentsGliosisHumansPlaque, AmyloidNeuroprotective Agents3D cultureAlzheimer's diseaseBioengineeringScreening

Identifiers

PMID35537596
PMCPMC12412061
OpenAlexW4229336288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.