Evidence map›Paper›PMID 35537469›Full record

ReviewAnnual review of genomics and human genetics2022

Ethical Guidance in Human Paleogenomics: New and Ongoing Perspectives.

Raquel E Fleskes, Alyssa C Bader, Krystal S Tsosie, Jennifer K Wagner, Katrina G Claw, Nanibaa' A Garrison

Abstract readReview
In one paragraph

Review in Annual review of genomics and human genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026
    Review
  2. Review
  3. Considerations for biobanking of nonhuman genome data connected to Indigenous Peoples and lands.Conservation biology : the journal of the Society for Conservation Biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Ethics and applications of isotope analysis in archaeology.American journal of biological anthropology · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Raquel E FleskesDepartment of Anthropology, University of Connecticut, Storrs, Connecticut, USA; email: raquel.fleskes@uconn.edu.
Alyssa C BaderDepartment of Anthropology, University of Colorado Boulder, Boulder, Colorado, USA; email: alyssa.bader@colorado.edu.
Krystal S TsosieNative BioData Consortium, Eagle Butte, South Dakota, USA; email: krystal@nativebio.org.
Jennifer K WagnerSchool of Engineering Design, Technology, and Professional Programs; Institute for Computational and Data Sciences; Department of Biomedical Engineering; and Rock Ethics Institute, Pennsylvania State University, University Park, Pennsylvania, USA; email: jkw131@psu.edu.
Katrina G ClawDivision of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA; email: katrina.claw@cuanschutz.edu.
Nanibaa' A GarrisonInstitute for Society and Genetics, Institute for Precision Health, and Division of General Internal Medicine and Health Services Research, University of California, Los Angeles, California, USA; email: nanibaa@socgen.ucla.edu.

Funding

Pharmacogenomic approaches to drug metabolism in American Indian/Alaska Native PeopleR35HG011319 · NHGRI · UNIVERSITY OF COLORADO DENVER · PI CLAW, KATRINA G · 2020 to 2024
$2.9M
NHGRI NIH HHS R35 HG011319
6 · The paper itself

Abstract

Over the past two decades, the study of ancient genomes from Ancestral humans, or human paleogenomic research, has expanded rapidly in both scale and scope. Ethical discourse has subsequently emerged to address issues of social responsibility and scientific robusticity in conducting research. Here, we highlight and contextualize the primary sources of professional ethical guidance aimed at paleogenomic researchers. We describe the tension among existing guidelines, while addressing core issues such as consent, destructive research methods, and data access and management. Currently, there is a dissonance between guidelines that focus on scientific outcomes and those that hold scientists accountable to stakeholder communities,such as descendants. Thus, we provide additional tools to navigate the complexities of ancient DNA research while centering engagement with stakeholder communities in the scientific process.

Indexed as

GenomicsPaleontologyDNA, AncientHumansInformed ConsentResearch PersonnelDNA, Ancientancient DNAconsentethicsIndigenouspaleogenomicsstakeholders

Identifiers

PMID35537469
PMCPMC11657320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.