Evidence map›Paper›PMID 35537344›Full record

ArticleLab on a chip2022

From saliva to SNP: non-invasive, point-of-care genotyping for precision medicine applications using recombinase polymerase amplification and giant magnetoresistive nanosensors.

Ana Sofia de Olazarra, Dana Lee Cortade, Shan X Wang

Open access · greenAbstract read
In one paragraph

Article in Lab on a chip, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Do Diabetes and Genetic Polymorphisms in theJournal of clinical medicine · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. A GMR enzymatic assay for quantifying nuclease and peptidase activity.Frontiers in bioengineering and biotechnology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ana Sofia de OlazarraDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305, USA. sxwang@stanford.edu.ORCID 0000-0001-5312-6852
Dana Lee CortadeDepartment of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-9267-4015
Shan X WangDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305, USA. sxwang@stanford.edu.ORCID 0000-0001-8420-9554
Stanford University · US

Funding

Graduate Training Program in BiotechnologyT32GM008412 · NIGMS · STANFORD UNIVERSITY · PI COCHRAN, JENNIFER R · 1991 to 2020
$5.5M
Giant MagnetoResistive (GMR) Sensors for Measuring Influenza VaccineR01AI125197 · NIAID · STANFORD UNIVERSITY · PI UTZ, PAUL JOSEPH, WANG, SHAN X. · 2016 to 2021
$5.0M
Rapid and affordable magneto-nanosensors for ctDNA-guided lung cancer managementR01CA257843 · NCI · STANFORD UNIVERSITY · PI WANG, SHAN X. · 2021 to 2024
$2.2M
NCI NIH HHS R01 CA257843NIAID NIH HHS R01 AI125197NIGMS NIH HHS T32 GM008412
6 · The paper itself

Abstract

Genetic testing is considered a cornerstone of the precision medicine paradigm. Genotyping of single nucleotide polymorphisms (SNPs) has been shown to provide insights into several important issues, including therapy selection and drug responsiveness. However, a scarcity of widely deployable and cost-effective genotyping tools has limited the integration of precision medicine into routine clinical practice. The objective of our work was to develop a portable, cost-effective, and automated platform that performs SNP genotyping at the point-of-care (POC). Using recombinase polymerase amplification (RPA) and giant magnetoresistive (GMR) nanosensors, we present a highly automated and multiplexed point-of-care platform that utilizes direct saliva for the qualitative genotyping of four SNPs (rs4633, rs4680, rs4818, rs6269) along the catechol-

Indexed as

Catechol O-MethyltransferasePolymorphism, Single NucleotideGenotypePoint-of-Care SystemsPrecision MedicineRecombinasesSalivaCatechol O-MethyltransferaseRecombinases

Identifiers

PMID35537344
PMCPMC9156572
OpenAlexW4280541029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.