Evidence map›Paper›PMID 35537100›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2022

Transient receptor potential cation channel 6 deficiency leads to increased body weight and metabolic dysfunction.

Zhen Wang, Jussara M do Carmo, Alexandre A da Silva, Yiling Fu, Lance T Jaynes, Jaylan Sears, Xuan Li, Alan J Mouton, Ana Carolina M Omoto, Brittney P Xu and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Zhen WangDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0002-8028-8942
Jussara M do CarmoDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0003-0471-0512
Alexandre A da SilvaDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0003-4504-0607
Yiling FuDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Lance T JaynesDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Jaylan SearsDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0001-5381-3919
Xuan LiDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0001-5781-1662
Alan J MoutonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Ana Carolina M OmotoDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Brittney P XuDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
John E HallDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Jackson Memorial Hospital · US

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI HALL, JOHN E · 1993 to 2018
$39.4M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GRANGER, JOEY P. · 2016 to 2025
$38.2M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Long-term consequences of parental obesity on developmental programming of cardiorenal diseases in offspringR01DK121411 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI DO CARMO, JUSSARA M. · 2019 to 2021
$818k
Mechanisms of Synergistic Interactions of Hypertension and Diabetes in Promoting Kidney InjuryR00DK113280 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI WANG, ZHEN · 2018 to 2020
$747k
NHLBI NIH HHS P01 HL051971NIDDK NIH HHS R00 DK113280NIDDK NIH HHS R01 DK121411NIGMS NIH HHS P20 GM104357NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Transient receptor potential cation channel 6 (TRPC6), a member of the TRPC family, is expressed in the hypothalamus and modulates cell Ca

Indexed as

TRPC6 Cation ChannelWeight GainAnimalsAnorexiaBlood PressureBody WeightEatingFemaleLeptinMaleMiceMice, KnockoutObesityLeptinTRPC6 Cation ChannelTrpc6 protein, mouseblood pressureenergy expenditurefood intakeleptin, obesity

Identifiers

PMID35537100
PMCPMC9190745
OpenAlexW4229454217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.