Evidence map›Paper›PMID 35536885›Full record

ArticleScience signaling2022

Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling.

Chirag Vasavda, Evan R Semenza, Jason Liew, Ruchita Kothari, Ryan S Dhindsa, Shruthi Shanmukha, Anthony Lin, Robert Tokhunts, Cristina Ricco, Adele M Snowman and 9 more

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Biliverdin reductase A is a major determinant of protective NRF2 signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 2 countries.

Chirag VasavdaSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-4558-4698
Evan R SemenzaSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-3494-6542
Jason LiewSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-9649-3617
Ruchita KothariSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ryan S DhindsaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8965-0813
Shruthi ShanmukhaSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-5659-2250
Anthony LinDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Robert TokhuntsDepartment of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03766, USA.ORCID 0000-0002-8922-2595
Cristina RiccoRobert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
Adele M SnowmanSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Lauren AlbacarysSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Francesco PastoreDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome 00168, Italy.ORCID 0000-0003-0064-1505
Cristian RipoliDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome 00168, Italy.ORCID 0000-0002-5315-0163
Claudio GrassiDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome 00168, Italy.ORCID 0000-0001-7253-1685
Eugenio BaroneDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, Rome 00185, Italy.ORCID 0000-0002-7028-4251
Michael D KornbergDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-2588-7325
Xinzhong DongSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-9750-7718
Bindu D PaulSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-1862-6103
Solomon H SnyderSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-6818-7022
Johns Hopkins University · USUniversità Cattolica del Sacro Cuore · ITBaylor College of Medicine · USDartmouth–Hitchcock Medical Center · USHoward Hughes Medical Institute · USRutgers, The State University of New Jersey · USSapienza University of Rome · ITUniversity of California, San Francisco · US

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
NEUROCHEMICAL ACTIONS OF PSYCHOTROPIC DRUGSR01MH018501 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SNYDER, SOLOMON H. · 1985 to 2019
$10.8M
Thorase Regulation of the Actions of CocaineP50DA044123 · NIDA · JOHNS HOPKINS UNIVERSITY · PI DAWSON, VALINA L., JANAK, PATRICIA H. · 2018 to 2022
$9.0M
Neuroprotective actions of cystathionine g-lyase through gasotransmitter hydrogen sulfide signalingR01AG071512 · NIA · JOHNS HOPKINS UNIVERSITY · PI Bindu Paul · 2022 to 2026
$3.4M
Role of sulfhydration on the functions of the microtubule associated protein, TauR21AG073684 · NIA · JOHNS HOPKINS UNIVERSITY · PI PAUL, BINDU · 2021 to 2022
$450k
NIA NIH HHS R01 AG071512NIA NIH HHS R21 AG073684NIDA NIH HHS P50 DA044123NIGMS NIH HHS T32 GM136577NIMH NIH HHS R01 MH018501
6 · The paper itself

Abstract

Synapses connect discrete neurons into vast networks that send, receive, and encode diverse forms of information. Synaptic function and plasticity, the neuronal process of adapting to diverse and variable inputs, depend on the dynamic nature of synaptic molecular components, which is mediated in part by cell adhesion signaling pathways. Here, we found that the enzyme biliverdin reductase (BVR) physically links together key focal adhesion signaling molecules at the synapse.

Indexed as

Focal Adhesion Kinase 2Oxidoreductases Acting on CH-CH Group DonorsAnimalsFocal Adhesion Protein-Tyrosine KinasesMicePhosphorylationReceptors, N-Methyl-D-Aspartatesrc-Family Kinasesbiliverdin reductaseFocal Adhesion Kinase 2Focal Adhesion Protein-Tyrosine KinasesOxidoreductases Acting on CH-CH Group DonorsReceptors, N-Methyl-D-Aspartatesrc-Family Kinases

Identifiers

PMID35536885
PMCPMC9281001
OpenAlexW4280560442

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.