ArticlePLoS neglected tropical diseases2022
Seropositivity for Coxiella burnetii in suspected patients with dengue in São Paulo state, Brazil.
Article in PLoS neglected tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 22 citations in OpenAlex.
- Epidemiological investigation of a clinical case of Q fever in the Brazilian Amazon.Parasite epidemiology and control · 2026Article
- Q fever outbreak in a slaughterhouse in Brazil: description and decade-later investigation.Infection · 2026Article
- Article
- Coxiella burnetii and HIV infection in people experiencing homelessness.Scientific reports · 2025Article
- Bartonella spp., Coxiella burnetii and Rickettsia rickettsii in urban bats: molecular investigation of neglected zoonoses in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- One health behind bars: Seroincidence ofOne health (Amsterdam, Netherlands) · 2025Article
- Raw Equid Milk: A Potential Risk for Q Fever?Animals : an open access journal from MDPI · 2025Article
- One Health approach toFrontiers in public health · 2025Article
- Unveiling Q fever in Latin America: beyond occupational risks to vulnerable populations and environmental transmission.Frontiers in public health · 2025Article
- Prevalent zoonoses in Sao Paulo State, Brazil: the role of bats and molecular diagnosis.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Review
- Spatial distribution of Q fever in sheep and goats of selective villages of Punjab Province, Pakistan.BMC veterinary research · 2024Article
- Delayed diagnosis of persistent Q fever: a case series from China.BMC infectious diseases · 2024Article
- Article
- One Health approach to Coxiella burnetii in Brazilian indigenous communities.Scientific reports · 2024Article
- Serosurvey ofTropical medicine and infectious disease · 2024Article
- Serosurvey ofMicroorganisms · 2024Article
- Clinical and Epidemiological Aspects of Acute Q Fever in Reunion Island over Fourteen Years: A Retrospective Cohort Study.Microorganisms · 2023Article
- Comparison of Three Serologic Tests for the Detection of Anti-Pathogens (Basel, Switzerland) · 2023Article
- Overview of Q fever in Brazil: an underestimated zoonosis.Revista do Instituto de Medicina Tropical de Sao Paulo · 2023Review
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9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Q fever and brucellosis are zoonoses that cause fever and other systemic clinical signs in humans; their occurrences are neglected and the differential diagnosis for some diseases is disregarded. This study aimed to investigate the seropositivity for Coxiella burnetii and Brucella spp. antibodies in patients suspected of dengue from 38 municipalities in the state of São Paulo, Brazil. The samples (n = 604) were obtained by convenience from the Adolfo Lutz Institute serum bank. Sera were subjected to an indirect immunofluorescence assay (IFA) using in-house and commercial diagnostic protocols to evaluate C. burnetii positivity. For Brucella spp., sera were subjected to rapid plate serum agglutination with buffered acidified antigen (AAT), slow tube serum agglutination (SAL), and 2-mercaptoethanol (2-ME) techniques. Associations and statistical inferences of the results were performed by logistic regression according to the clinical and demographic variables collected from the patients. Statistical analyses were performed using Statistical Analysis Software (SAS) and associations were considered when p value was <0.05. In all, 129 patients showed positive results for Q fever, indicating a seropositivity of 21.4% (95% CI 18.15-24.85). Patients with 14-20 days of symptoms had 2.12 (95% CI 1.34-3.35) times more chances of being seropositive for Q fever than patients with 7-13 days, and patients with 21-27 days of fever had 2.62 (95% CI 1.27-5.41) times more chances of being seropositive for Q fever than patients with 7-13 days. For the other variables analyzed, there were no significant associations between the groups. No positivity for brucellosis was observed. This is the most comprehensive study of people seropositive for Q fever in São Paulo state and provides additional data for the medical community in Brazil. It is suggested that Q fever may be an important differential diagnosis of febrile illnesses in the region, demanding the government's attention and investment in health.
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