ArticlePLoS computational biology2022
Superinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks.
Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Rational Design of a Phage Cocktail for Effective Control of Multidrug-Resistant UropathogenicAntibiotics (Basel, Switzerland) · 2026Article
- The value of a prophage-borne defense system in phage-phage competition.PLoS computational biology · 2026Article
- Host physiology-dependent lysis timing shapes bacteriophage competition under nutrient fluctuations.mSystems · 2026Article
- Double trouble: how co- and superinfections shape viral dynamics and host responses.Journal of virology · 2026Review
- Characterization of a novel phage-plasmid vB_EcoM_ED targeting multidrug-resistant Escherichia coli isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Analysis of a Novel T1-like Phage KanT1 Reveals a Standalone SH3 Domain as a Widespread Component ofInternational journal of molecular sciences · 2026Article
- Live and let die: Lysis time variability and resource limitation shape lytic bacteriophage fitness.PLoS computational biology · 2026Article
- Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback.Nature ecology & evolution · 2026Article
- Ecological ubiquity and phylogeny drive nestedness in phages-bacteria networks and shape the bacterial defensome.PLoS pathogens · 2025Article
- Potyvirus HcPro Suppressor of RNA Silencing Induces PVY Superinfection Exclusion in a Strain-Specific Manner.International journal of molecular sciences · 2025Article
- In Planta Application and Efficacy of FireFighter-A Phage Cocktail for Combating Fire Blight.The plant pathology journal · 2025Article
- The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes.Science advances · 2025Article
- Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback.bioRxiv : the preprint server for biology · 2025Article
- Article
- Borna disease virus 2 maintains genomic polymorphisms by superinfection in persistently infected cells.Npj viruses · 2025Article
- Description of two novel bacteriophages of the class Caudoviricetes that infect Ralstonia solanacearum and Ralstonia pseudosolanacearum.Archives of virology · 2025Article
- Incomplete lytic cycle of a widespread Bacteroides bacteriophage leads to the formation of defective viral particles.PLoS biology · 2025Article
- Navigating a Fine Balance: Point-Mutant Cheater Viruses Disrupt the Viral Replication Cycle.Molecular biology and evolution · 2025Article
- Phage-phage competition and biofilms affect interactions between two virulent bacteriophages and Pseudomonas aeruginosa.The ISME journal · 2025Article
- Provirus deletion frommicroLife · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral superinfection occurs when multiple viral particles subsequently infect the same host. In nature, several viral species are found to have evolved diverse mechanisms to prevent superinfection (superinfection exclusion) but how this strategic choice impacts the fate of mutations in the viral population remains unclear. Using stochastic simulations, we find that genetic drift is suppressed when superinfection occurs, thus facilitating the fixation of beneficial mutations and the removal of deleterious ones. Interestingly, we also find that the competitive (dis)advantage associated with variations in life history parameters is not necessarily captured by the viral growth rate for either infection strategy. Putting these together, we then show that a mutant with superinfection exclusion will easily overtake a superinfecting population even if the latter has a much higher growth rate. Our findings suggest that while superinfection exclusion can negatively impact the long-term adaptation of a viral population, in the short-term it is ultimately a winning strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.